Homogeneously staining region in a retinoblastoma cell line: relevance to tumor initiation and progression

A human retinoblastoma cell line was found to contain a homogeneously staining region (HSR) on chromosome 1 (at 1p34). An HSR had previously been identified at the same site in a human neuroblastoma cell line. Of the original retinoblastoma line, a subpopulation was found which did not contain the 1...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1981-08, Vol.67 (2), p.301-306
Main Authors: Gilbert, F, Balaban, G, Breg, W R, Gallie, B, Reid, T, Nichols, W
Format: Article
Language:English
Subjects:
Cell Line
Chromosome Aberrations - genetics
Chromosome Banding
Chromosome Disorders
Chromosomes - analysis
Eye Neoplasms - genetics
Eye Neoplasms - ultrastructure
Female
Freezing
Humans
Karyotyping
Metaphase
Retinoblastoma - genetics
Retinoblastoma - ultrastructure
Staining and Labeling
Time Factors
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Summary:A human retinoblastoma cell line was found to contain a homogeneously staining region (HSR) on chromosome 1 (at 1p34). An HSR had previously been identified at the same site in a human neuroblastoma cell line. Of the original retinoblastoma line, a subpopulation was found which did not contain the 1pHSR but did contain a 3p+ chromosome in which the additional segment resembled a small HSR. The 3p+ was most likely the result of the translocation between the 1pHSR and the short arm of a chromosome 3. Preliminary results also indicate that the retinoblastoma cells with the 1pHSR produced tumors in athymic nu/nu mice in an average of 28 days, while identical numbers of the retinoblastoma cells with the 3p+ (probable HSR) produced tumors in an average of 75 days.
ISSN:0027-8874