Soluble CD40L: Risk prediction after acute coronary syndromes

Elevated plasma concentrations of soluble CD40 ligand (sCD40L) indicate increased risk for future cardiovascular events in apparently healthy women. This study tested the hypothesis that plasma sCD40L, alone or in combination with troponin (cTnI) or C-reactive protein (CRP), may identify patients wi...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-09, Vol.108 (9), p.1049-1052
Main Authors: VARO, Nerea, DE LEMOS, James A, LIBBY, Peter, MORROW, David A, MURPHY, Sabina A, NUZZO, Rebecca, GIBSON, C. Michael, CANNON, Christopher P, BRAUNWALD, Eugene, SCHONBECK, Uwe
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Biological and medical sciences
C-Reactive Protein - analysis
Cardiology. Vascular system
Case-Control Studies
CD40 Ligand - blood
Coronary Disease - diagnosis
Coronary Disease - mortality
Coronary heart disease
Female
Heart
Heart Failure - epidemiology
Humans
Male
Medical sciences
Myocardial Infarction - epidemiology
Prognosis
Risk Factors
Syndrome
Troponin I - blood
Citations: Items that this one cites
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Summary:Elevated plasma concentrations of soluble CD40 ligand (sCD40L) indicate increased risk for future cardiovascular events in apparently healthy women. This study tested the hypothesis that plasma sCD40L, alone or in combination with troponin (cTnI) or C-reactive protein (CRP), may identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events. In a nested case-control study (cases, n=195; controls, n=195) within the OPUS-TIMI16 trial, patients with the prespecified study end points death, myocardial infarction (MI), or congestive heart failure (CHF) within 10 months had significantly higher median (25th, 75th percentiles) sCD40L plasma levels than did controls (0.78 [0.34, 1.73] ng/mL versus 0.52 [0.16, 1.42] ng/mL, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000088521.04017.13