Spontaneous Diabetes in Rats: Destruction of Islets is Prevented by Immunological Tolerance

Spontaneous diabetes occurring in ``BB'' rats (derived from a colony of outbred Wistar rats) is the result of destruction of pancreatic islets by infiltrating mononuclear cells (insulitis) and may be a disease very similar to human juvenile onset diabetes. Both diseases probably have an au...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-09, Vol.213 (4514), p.1390-1392
Main Authors: Naji, Ali, Silvers, Willys K., Bellgrau, Don, Barker, Clyde F.
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Autoimmune Diseases - immunology
Bone marrow cells
Bone Marrow Transplantation
Diabetes
Diabetes complications
Diabetes Mellitus, Experimental - immunology
Diabetes research
Disease Models, Animal
Graft Rejection
Immune Tolerance
Islands of Langerhans
Islets of Langerhans
Islets of Langerhans - immunology
Islets of Langerhans Transplantation
Rats
T lymphocytes
Transplantation
Type 1 diabetes mellitus
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Summary:Spontaneous diabetes occurring in ``BB'' rats (derived from a colony of outbred Wistar rats) is the result of destruction of pancreatic islets by infiltrating mononuclear cells (insulitis) and may be a disease very similar to human juvenile onset diabetes. Both diseases probably have an autoimmune etiology. Evidence is presented that islets transplanted to diabetic BB rats are destroyed by the original disease process. Inoculation of bone marrow from normal (nondiabetes-susceptible) rat donors into neonatal BB recipients usually prevents the development of hyperglycemia.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6791286