Spontaneous Diabetes in Rats: Destruction of Islets is Prevented by Immunological Tolerance

Spontaneous diabetes occurring in ``BB'' rats (derived from a colony of outbred Wistar rats) is the result of destruction of pancreatic islets by infiltrating mononuclear cells (insulitis) and may be a disease very similar to human juvenile onset diabetes. Both diseases probably have an au...

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Published in:Science (American Association for the Advancement of Science) 1981-09, Vol.213 (4514), p.1390-1392
Main Authors: Naji, Ali, Silvers, Willys K., Bellgrau, Don, Barker, Clyde F.
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Autoimmune Diseases - immunology
Bone marrow cells
Bone Marrow Transplantation
Diabetes
Diabetes complications
Diabetes Mellitus, Experimental - immunology
Diabetes research
Disease Models, Animal
Graft Rejection
Immune Tolerance
Islands of Langerhans
Islets of Langerhans
Islets of Langerhans - immunology
Islets of Langerhans Transplantation
Rats
T lymphocytes
Transplantation
Type 1 diabetes mellitus
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container_title Science (American Association for the Advancement of Science)
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creator Naji, Ali
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description Spontaneous diabetes occurring in ``BB'' rats (derived from a colony of outbred Wistar rats) is the result of destruction of pancreatic islets by infiltrating mononuclear cells (insulitis) and may be a disease very similar to human juvenile onset diabetes. Both diseases probably have an autoimmune etiology. Evidence is presented that islets transplanted to diabetic BB rats are destroyed by the original disease process. Inoculation of bone marrow from normal (nondiabetes-susceptible) rat donors into neonatal BB recipients usually prevents the development of hyperglycemia.
doi_str_mv 10.1126/science.6791286
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ispartof Science (American Association for the Advancement of Science), 1981-09, Vol.213 (4514), p.1390-1392
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language eng
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source American Association for the Advancement of Science; JSTOR Archival Journals
subjects Animals
Autoimmune diseases
Autoimmune Diseases - immunology
Bone marrow cells
Bone Marrow Transplantation
Diabetes
Diabetes complications
Diabetes Mellitus, Experimental - immunology
Diabetes research
Disease Models, Animal
Graft Rejection
Immune Tolerance
Islands of Langerhans
Islets of Langerhans
Islets of Langerhans - immunology
Islets of Langerhans Transplantation
Rats
T lymphocytes
Transplantation
Type 1 diabetes mellitus
title Spontaneous Diabetes in Rats: Destruction of Islets is Prevented by Immunological Tolerance
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