Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

• Published in: Neuroscience letters 2003-10, Vol.349 (3), p.209-211
• Main Authors: Zhang, Peng, Yang, Ze, Zhang, Chuanfang, Lu, Zeping, Shi, Xiaohong, Zheng, Weidong, Wan, Chunling, Zhang, Duanyang, Zheng, Chenguang, Li, Shu, Jin, Feng, Wang, Li
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Apolipoprotein E; Apolipoprotein E4; Apolipoproteins E - genetics; Biological and medical sciences; Brain - metabolism; Brain - physiopathology; Brain Chemistry - genetics; China - ethnology; Chinese; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DNA Mutational Analysis; Female; Gene Frequency - genetics; Gene polymorphisms; Genetic Predisposition to Disease - genetics; Genetic Testing; Genotype; Humans; Male; Medical sciences; Neurology; Polymorphism, Genetic - genetics; Risk Factors; Transferrin; Transferrin - genetics
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(03)00837-1

To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24–10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.