Treatment of neuroblastoma with intraspinal extensions

Neuroblastoma is the most common malignant cause of spinal compression in the paediatric population. Chemotherapy is commonly considered as the first-line treatment for these patients. The role of neurosurgical decompression and radiotherapy are still controversial. Thirteen children diagnosed as ha...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2003-09, Vol.10 (5), p.579-583
Main Authors: Yiin, Jia-Jean, Chang, Cheng-Siu, Jan, Yee-Jee, Wang, Yeou-Chih
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
chemotherapy
Child
Child, Preschool
Combined Modality Therapy
Female
Humans
Infant
intraspinal
laminectomy
Male
Mediastinal Neoplasms - pathology
Medical sciences
Neoplasm Invasiveness
neuroblastoma
Neuroblastoma - drug therapy
Neuroblastoma - pathology
Neuroblastoma - radiotherapy
Neuroblastoma - surgery
Neurology
Retroperitoneal Neoplasms - pathology
Spinal Neoplasms - drug therapy
Spinal Neoplasms - pathology
Spinal Neoplasms - radiotherapy
Spinal Neoplasms - surgery
Treatment Outcome
Tumors of the nervous system. Phacomatoses
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Summary:Neuroblastoma is the most common malignant cause of spinal compression in the paediatric population. Chemotherapy is commonly considered as the first-line treatment for these patients. The role of neurosurgical decompression and radiotherapy are still controversial. Thirteen children diagnosed as having neuroblastoma with intraspinal extension were included in this report. All patients presented with neurological deficits and were treated with chemotherapy initially, after which 3 patients recovered, 4 improved and 6 were aggravated into paraplegia. Two of the 6 aggravated patients received emergent laminectomy with removal of intraspinal tumour and recovered satisfactorily. Although spread of tumour into the spinal canal indicates an advanced disease, aggressive treatments such as chemotherapy and surgical resection can often improve neurological symptoms and life quality. Neurological decompression is recommended for patients with intraspinal neuroblastoma and rapid neurological deterioration during chemotherapy.
ISSN:0967-5868
1532-2653
DOI:10.1016/S0967-5868(03)00064-X