Semiautomated Assay for Indapamide in Biological Fluids

A sensitive fluorescence procedure for the determination of indapamide in plasma and whole blood was developed. The procedure requires preextraction of the biological sample followed by continuous-flow analysis. The assay is sensitive to indapamide levels of 25 ng/ml in plasma and blood. A linear re...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1981-03, Vol.70 (3), p.306-308
Main Authors: Grebowx, Peter E., Treitman, Jo A., Yeung, Anne K., Johnston, Martha M.
Format: Article
Language:English
Subjects:
and urine
Antihypertensives-semiautomated assay of indapamide in biological fluids
Autoanalysis
Diuretics - blood
Fluorometry
Fluorometry-analysis
Fluorometry—analysis, indapamide in plasma, whole blood, and urine
Humans
Indapamide - blood
indapamide in plasma
Indapamide-semiautomated assay in biological fluids
whole blood
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Summary:A sensitive fluorescence procedure for the determination of indapamide in plasma and whole blood was developed. The procedure requires preextraction of the biological sample followed by continuous-flow analysis. The assay is sensitive to indapamide levels of 25 ng/ml in plasma and blood. A linear response from 25 to 200 ng/ml is observed. The procedure also can be used to measure urinary levels of indapamide. The assay has been used to obtain whole blood and plasma level curves from subjects receiving 2.5mg of indapamide.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600700321