The Wnt signaling pathway in solid childhood tumors

The Wnt signaling pathway has long been known to direct growth and patterning during embryonic development. Recent evidence also implicates this pathway in the development of childhood tumors of the liver, the kidney, the brain, and the pancreas. Here, we review the current evidence on how constitut...

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Bibliographic Details
Published in:Cancer Letters 2003-08, Vol.198 (2), p.123-138
Main Authors: Koesters, Robert, Doeberitz, Magnus von Knebel
Format: Article
Language:English
Subjects:
Adenomatous polyposis coli
Antineoplastic agents
Biological and medical sciences
Cell Transformation, Neoplastic
Child
Genes
Hepatoblastoma
Humans
Kinases
Medical sciences
Medulloblastoma
Mutation
Mutations
Neoplasms - genetics
Neoplasms - physiopathology
Nephroblastoma
Pancreatoblastoma
Pharmacology. Drug treatments
Primitive neuroectodermal tumor (PNET)
Protein-Tyrosine Kinases - metabolism
Proto-Oncogene Proteins - physiology
Rodents
Signal Transduction
Stem cells
Tumors
Wilms tumor
Wnt Proteins
Wnt signaling pathway
Zebrafish Proteins
β-Catenin
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Summary:The Wnt signaling pathway has long been known to direct growth and patterning during embryonic development. Recent evidence also implicates this pathway in the development of childhood tumors of the liver, the kidney, the brain, and the pancreas. Here, we review the current evidence on how constitutive activation of the Wnt signaling pathway may occur in hepato-, nephro-, medullo- and pancreatoblastomas. With particular emphasis the mutational activation of CTNNB1, an emerging major oncogene in solid childhood tumors, is discussed.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(03)00367-7