Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhage

Lipoprotein particles (Lps) in normal human cerebrospinal fluid (CSF) are distinct from those found in plasma and include unique apolipoprotein E (apoE indicates protein; APOE, gene) containing lipoproteins rarely seen in human plasma. Less favourable neurological recovery after subarachnoid hemorrh...

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Bibliographic Details
Published in:Atherosclerosis 2003-09, Vol.170 (1), p.141-146
Main Authors: Kay, A.D., Day, S.P., Nicoll, J.A.R., Packard, C.J., Caslake, M.J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aneurysm, Ruptured - cerebrospinal fluid
Apolipoprotein A-I - cerebrospinal fluid
Apolipoproteins E - cerebrospinal fluid
Area Under Curve
Biological and medical sciences
Brain injury
Cerebrospinal fluid
Cerebrospinal Fluid Proteins - analysis
Humans
Lipoproteins
Lipoproteins - blood
Lipoproteins - cerebrospinal fluid
Lipoproteins, HDL - cerebrospinal fluid
Lipoproteins, LDL - cerebrospinal fluid
Lipoproteins, VLDL - cerebrospinal fluid
Medical sciences
Middle Aged
Neurology
Particle Size
Phospholipids - cerebrospinal fluid
Statistics as Topic
Subarachnoid hemorrhage
Subarachnoid Hemorrhage - cerebrospinal fluid
United Kingdom
Vascular diseases and vascular malformations of the nervous system
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Summary:Lipoprotein particles (Lps) in normal human cerebrospinal fluid (CSF) are distinct from those found in plasma and include unique apolipoprotein E (apoE indicates protein; APOE, gene) containing lipoproteins rarely seen in human plasma. Less favourable neurological recovery after subarachnoid hemorrhage (SAH) has been observed in patients who posses the APOE ε4 allele raising the possibility that apoE influences neuronal survival after brain injury. We analysed Lps from control and SAH CSF testing the hypotheses that following brain injury CSF Lps undergo remodelling and apoE containing Lps are selectively depleted from brain injury CSF. Lipoproteins were fractionated using CSF from six control pools and six patients with SAH on a sepharose 6HR 10/30 size exclusion column. Fractions were assayed for total cholesterol (TC), free cholesterol (FC), phospholipid, triglyceride (TG), apoE, apolipoprotein B (apoB), and apolipoprotein AI (apoAI). Compared to control CSF there were significant ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(03)00249-1