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Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein
The M protein on the surface of Streptococcus pyogenes cells enables the organisms to resist ingestion and killing by phagocytic cells in the blood of the non-immune host. In the immune host, type-specific antibodies against the M protein neutralize the antiphagocytic effect and allow the rapid elim...
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| Published in: | Nature (London) 1981-07, Vol.292 (5822), p.457-459 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c335t-2f06bb55edaf2e9aac5aa5d586f4fe3ae81f5a35710163eb3aee87377bf01a6b3 |
| container_end_page | 459 |
| container_issue | 5822 |
| container_start_page | 457 |
| container_title | Nature (London) |
| container_volume | 292 |
| creator | Beachey, Edwin H Seyer, Jerome M Dale, James B Simpson, W. Andrew Kang, Andrew H |
| description | The M protein on the surface of
Streptococcus pyogenes
cells enables the organisms to resist ingestion and killing by phagocytic cells in the blood of the non-immune host. In the immune host, type-specific antibodies against the M protein neutralize the antiphagocytic effect and allow the rapid elimination of any invading streptococcci having the same serotype of M protein. Recent studies
1
in our laboratories of the primary structure of one of these M proteins (type 24) have indicated that the molecule is composed of repeating covalent structures, each of which contains protective antigenic determinants. These results suggest that only a small portion of the M protein molecule may be required to produce primary protective immunity against
S. pyogenes
. We now report that this notion is well founded. Our findings may have a bearing on the development of M-protein vaccines to protect against streptococcal infections causing acute rheumatic fever and rheumatic heart disease
2
. |
| doi_str_mv | 10.1038/292457a0 |
| format | article |
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Streptococcus pyogenes
cells enables the organisms to resist ingestion and killing by phagocytic cells in the blood of the non-immune host. In the immune host, type-specific antibodies against the M protein neutralize the antiphagocytic effect and allow the rapid elimination of any invading streptococcci having the same serotype of M protein. Recent studies
1
in our laboratories of the primary structure of one of these M proteins (type 24) have indicated that the molecule is composed of repeating covalent structures, each of which contains protective antigenic determinants. These results suggest that only a small portion of the M protein molecule may be required to produce primary protective immunity against
S. pyogenes
. We now report that this notion is well founded. Our findings may have a bearing on the development of M-protein vaccines to protect against streptococcal infections causing acute rheumatic fever and rheumatic heart disease
2
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/292457a0</identifier><identifier>PMID: 6166868</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Antibody Formation ; Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Proteins - immunology ; Carrier Proteins ; Epitopes ; Humanities and Social Sciences ; Immunity, Cellular ; letter ; Mice ; multidisciplinary ; Oligopeptides - chemical synthesis ; Oligopeptides - immunology ; Rabbits ; Science ; Science (multidisciplinary) ; Vaccines</subject><ispartof>Nature (London), 1981-07, Vol.292 (5822), p.457-459</ispartof><rights>Springer Nature Limited 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-2f06bb55edaf2e9aac5aa5d586f4fe3ae81f5a35710163eb3aee87377bf01a6b3</citedby><cites>FETCH-LOGICAL-c335t-2f06bb55edaf2e9aac5aa5d586f4fe3ae81f5a35710163eb3aee87377bf01a6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6166868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beachey, Edwin H</creatorcontrib><creatorcontrib>Seyer, Jerome M</creatorcontrib><creatorcontrib>Dale, James B</creatorcontrib><creatorcontrib>Simpson, W. Andrew</creatorcontrib><creatorcontrib>Kang, Andrew H</creatorcontrib><title>Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>The M protein on the surface of
Streptococcus pyogenes
cells enables the organisms to resist ingestion and killing by phagocytic cells in the blood of the non-immune host. In the immune host, type-specific antibodies against the M protein neutralize the antiphagocytic effect and allow the rapid elimination of any invading streptococcci having the same serotype of M protein. Recent studies
1
in our laboratories of the primary structure of one of these M proteins (type 24) have indicated that the molecule is composed of repeating covalent structures, each of which contains protective antigenic determinants. These results suggest that only a small portion of the M protein molecule may be required to produce primary protective immunity against
S. pyogenes
. We now report that this notion is well founded. Our findings may have a bearing on the development of M-protein vaccines to protect against streptococcal infections causing acute rheumatic fever and rheumatic heart disease
2
.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>Antigens, Bacterial</subject><subject>Bacterial Outer Membrane Proteins</subject><subject>Bacterial Proteins - immunology</subject><subject>Carrier Proteins</subject><subject>Epitopes</subject><subject>Humanities and Social Sciences</subject><subject>Immunity, Cellular</subject><subject>letter</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - immunology</subject><subject>Rabbits</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vaccines</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><recordid>eNptkMtKxDAUhoMoOl7AF1CyEl1Uk6a5zFLEGyguHNclTU80Om1qkgp9ezt0nJWrcPJ_fIfzI3RMySUlTF3l87zgUpMtNKOFFFkhlNxGM0JylRHFxB7aj_GTEMKpLHbRrqBCKKFmSC-GDrLYgXHWGdwFn8Ak9wPYNU3fujRg-PFfUONqwHFo0wekFQddcjVgb_FrCuPgjTemj7gb_Du0EPHz5HLtIdqxehnhaP0eoLe728XNQ_b0cv94c_2UGcZ4ynJLRFVxDrW2Ocy1NlxrXnMlbGGBaVDUcs24pIQKBtX4A0oyKStLqBYVO0Bnk3fc-91DTGXjooHlUrfg-1hKJnIi-XwEzyfQBB9jAFt2wTU6DCUl5arN8q_NET1ZO_uqgXoDrusb84spj2PSvkMoP30f2vHM_1ynE9vq1AfYuDbAL2xDiSk</recordid><startdate>19810730</startdate><enddate>19810730</enddate><creator>Beachey, Edwin H</creator><creator>Seyer, Jerome M</creator><creator>Dale, James B</creator><creator>Simpson, W. Andrew</creator><creator>Kang, Andrew H</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810730</creationdate><title>Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein</title><author>Beachey, Edwin H ; Seyer, Jerome M ; Dale, James B ; Simpson, W. Andrew ; Kang, Andrew H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-2f06bb55edaf2e9aac5aa5d586f4fe3ae81f5a35710163eb3aee87377bf01a6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antigens, Bacterial</topic><topic>Bacterial Outer Membrane Proteins</topic><topic>Bacterial Proteins - immunology</topic><topic>Carrier Proteins</topic><topic>Epitopes</topic><topic>Humanities and Social Sciences</topic><topic>Immunity, Cellular</topic><topic>letter</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - immunology</topic><topic>Rabbits</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beachey, Edwin H</creatorcontrib><creatorcontrib>Seyer, Jerome M</creatorcontrib><creatorcontrib>Dale, James B</creatorcontrib><creatorcontrib>Simpson, W. Andrew</creatorcontrib><creatorcontrib>Kang, Andrew H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beachey, Edwin H</au><au>Seyer, Jerome M</au><au>Dale, James B</au><au>Simpson, W. Andrew</au><au>Kang, Andrew H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1981-07-30</date><risdate>1981</risdate><volume>292</volume><issue>5822</issue><spage>457</spage><epage>459</epage><pages>457-459</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>The M protein on the surface of
Streptococcus pyogenes
cells enables the organisms to resist ingestion and killing by phagocytic cells in the blood of the non-immune host. In the immune host, type-specific antibodies against the M protein neutralize the antiphagocytic effect and allow the rapid elimination of any invading streptococcci having the same serotype of M protein. Recent studies
1
in our laboratories of the primary structure of one of these M proteins (type 24) have indicated that the molecule is composed of repeating covalent structures, each of which contains protective antigenic determinants. These results suggest that only a small portion of the M protein molecule may be required to produce primary protective immunity against
S. pyogenes
. We now report that this notion is well founded. Our findings may have a bearing on the development of M-protein vaccines to protect against streptococcal infections causing acute rheumatic fever and rheumatic heart disease
2
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6166868</pmid><doi>10.1038/292457a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1981-07, Vol.292 (5822), p.457-459 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73620759 |
| source | Nature |
| subjects | Amino Acid Sequence Animals Antibody Formation Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins - immunology Carrier Proteins Epitopes Humanities and Social Sciences Immunity, Cellular letter Mice multidisciplinary Oligopeptides - chemical synthesis Oligopeptides - immunology Rabbits Science Science (multidisciplinary) Vaccines |
| title | Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein |
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