Can tolerogenic dendritic cells help to modulate allo-immune responses in the setting of hematopoietic cell transplantation?

Recent evidence suggests that recipient as well as donor dendritic cell (DC) subsets are implicated in hematopoietic engraftment, graft-vs.-host disease occurrence, immune reconstitution and graft-vs.-leukemia effects observed after allogeneic hematopoietic cell transplantation. Although further dat...

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Bibliographic Details
Published in:Transplant immunology 2003-07, Vol.11 (3), p.259-266
Main Authors: Fresnay, Stéphanie, Garnache-Ottou, Francine, Plumas, Joel, Seilles, Estelle, Tiberghien, Pierre, Saas, Philippe
Format: Article
Language:English
Subjects:
Cell-based therapy
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - transplantation
Engraftment
Graft vs Host Disease - immunology
Graft vs Host Disease - therapy
Graft-vs.-host disease
Hematopoietic cell transplantation
Hematopoietic Stem Cell Transplantation
Humans
Immune Tolerance
Tolerance
Transplantation, Homologous
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Summary:Recent evidence suggests that recipient as well as donor dendritic cell (DC) subsets are implicated in hematopoietic engraftment, graft-vs.-host disease occurrence, immune reconstitution and graft-vs.-leukemia effects observed after allogeneic hematopoietic cell transplantation. Although further data are needed to better understand the precise role of different DC subsets, strategies based on their manipulation to obtain tolerogenic DC can be envisaged. Here, we propose that DC blocked in an immature stage, using immunosuppressive agents, or lymphoid DC can be adequate candidates to control the alloreactive conflict post-allograft.
ISSN:0966-3274
1878-5492
DOI:10.1016/S0966-3274(03)00053-4