Supported planar bilayers in studies on immune cell adhesion and communication

Supported planar bilayers have been used extensively in immunology to study molecular interactions at interfaces as a model for cell–cell interaction. Examples include Fc receptor-mediated adhesion and signaling and formation of the immunological synapse between T cells and antigen-presenting cells....

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Bibliographic Details
Published in:Journal of Immunological Methods 2003-07, Vol.278 (1), p.19-32
Main Authors: Groves, Jay T., Dustin, Michael L.
Format: Article
Language:English
Subjects:
Animals
Bilayer technology
Biological and medical sciences
Cell Adhesion - immunology
Cell Communication - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Imaging, Three-Dimensional
Immune cell adhesion
immunological synapses
Lipid Bilayers - immunology
Lymphocytes - immunology
Microscopy, Confocal
microtechnology
Models, Biological
Molecular immunology
Nanotechnology
Supported planar bilayers
Techniques
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Summary:Supported planar bilayers have been used extensively in immunology to study molecular interactions at interfaces as a model for cell–cell interaction. Examples include Fc receptor-mediated adhesion and signaling and formation of the immunological synapse between T cells and antigen-presenting cells. The advantage of the supported planar bilayer system is control of the bilayer composition and the optical advantages of imaging the cell–bilayer or bilayer–bilayer interface by various types of trans-, epi- and total internal reflection illumination. Supported planar bilayers are simple to form by liposome fusion and recent advances in micro- and nanotechnology greatly extend the power of supported bilayers to address key questions in immunology and cell biology.
ISSN:0022-1759
1872-7905
DOI:10.1016/S0022-1759(03)00193-5