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Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG c...
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| Published in: | FEBS letters 2003-09, Vol.551 (1), p.104-106 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5395-c122d1ebe19cfef76ea7c1b9cb405af3e199720180cf444ed2b8bffdfb4046dc3 |
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| cites | cdi_FETCH-LOGICAL-c5395-c122d1ebe19cfef76ea7c1b9cb405af3e199720180cf444ed2b8bffdfb4046dc3 |
| container_end_page | 106 |
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| container_start_page | 104 |
| container_title | FEBS letters |
| container_volume | 551 |
| creator | Russell, Aaron P Gastaldi, Giacomo Bobbioni-Harsch, Elisabetta Arboit, Patrizia Gobelet, Charles Dériaz, Olivier Golay, Alain Witztum, Joseph L Giacobino, Jean-Paul |
| description | Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance. |
| doi_str_mv | 10.1016/S0014-5793(03)00875-5 |
| format | article |
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We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(03)00875-5</identifier><identifier>PMID: 12965212</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>4-HNE, 4-hydroxynonenal ; 4-Hydroxynonenal ; Adult ; Aldehydes - analysis ; Endurance training ; ET, endurance-trained ; Humans ; IMTG, intra-myocellular triglycerides ; Intra-myocellular triglyceride ; Lipid Peroxidation ; Lipids - classification ; Male ; Middle Aged ; Muscle ; Muscle, Skeletal - chemistry ; Muscle, Skeletal - cytology ; Muscle, Skeletal - metabolism ; Obesity ; Obesity - metabolism ; ORO, Oil red oil ; Physical Endurance ; Triglycerides - analysis ; Triglycerides - metabolism</subject><ispartof>FEBS letters, 2003-09, Vol.551 (1), p.104-106</ispartof><rights>2003 Federation of European Biochemical Societies</rights><rights>FEBS Letters 551 (2003) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5395-c122d1ebe19cfef76ea7c1b9cb405af3e199720180cf444ed2b8bffdfb4046dc3</citedby><cites>FETCH-LOGICAL-c5395-c122d1ebe19cfef76ea7c1b9cb405af3e199720180cf444ed2b8bffdfb4046dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579303008755$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12965212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russell, Aaron P</creatorcontrib><creatorcontrib>Gastaldi, Giacomo</creatorcontrib><creatorcontrib>Bobbioni-Harsch, Elisabetta</creatorcontrib><creatorcontrib>Arboit, Patrizia</creatorcontrib><creatorcontrib>Gobelet, Charles</creatorcontrib><creatorcontrib>Dériaz, Olivier</creatorcontrib><creatorcontrib>Golay, Alain</creatorcontrib><creatorcontrib>Witztum, Joseph L</creatorcontrib><creatorcontrib>Giacobino, Jean-Paul</creatorcontrib><title>Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.</description><subject>4-HNE, 4-hydroxynonenal</subject><subject>4-Hydroxynonenal</subject><subject>Adult</subject><subject>Aldehydes - analysis</subject><subject>Endurance training</subject><subject>ET, endurance-trained</subject><subject>Humans</subject><subject>IMTG, intra-myocellular triglycerides</subject><subject>Intra-myocellular triglyceride</subject><subject>Lipid Peroxidation</subject><subject>Lipids - classification</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>ORO, Oil red oil</subject><subject>Physical Endurance</subject><subject>Triglycerides - analysis</subject><subject>Triglycerides - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkEtv1DAUha0K1E6H_oQirxBdpPiZB5sKqpYijdRF6dpy7OtiSOJgJwP99zgzI1iCZMnyveece_0hdE7JJSW0fPdACBWFrBr-lvALQupKFvIIrWhd8YKLsn6BVn8kJ-g0pW8kv2vaHKMTyppSMspWaLvxo7d4hBh-easnHwbsB5y-QweT7nA_J9MBDg6HFhJgnbAJ_agjWDwFDIOdox4MFFPUfsjFr3Ovh_Qea2x02hmfQrB4my5xqy3ulnHp6hV66XSX4Oxwr9Hj7c2X67tic__p8_WHTWEkb2RhKGOWQgu0MQ5cVYKuDG0b0woiteO53lQs_4oYJ4QAy9q6dc663BelNXyN3uxzxxh-zJAm1ftkoOv0AGFOquIlEyITWiO5F5oYUorg1Bh9r-OzokQtwNUOuFpoKpLPAlzJ7Ht9GDC3Pdi_rgPhLLjbC376Dp7_L1Xd3nxku87SIHxXXmZd7aMgE9t6iCoZDxm-9RHMpGzw_9j2N48YpWc</recordid><startdate>20030911</startdate><enddate>20030911</enddate><creator>Russell, Aaron P</creator><creator>Gastaldi, Giacomo</creator><creator>Bobbioni-Harsch, Elisabetta</creator><creator>Arboit, Patrizia</creator><creator>Gobelet, Charles</creator><creator>Dériaz, Olivier</creator><creator>Golay, Alain</creator><creator>Witztum, Joseph L</creator><creator>Giacobino, Jean-Paul</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030911</creationdate><title>Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?</title><author>Russell, Aaron P ; Gastaldi, Giacomo ; Bobbioni-Harsch, Elisabetta ; Arboit, Patrizia ; Gobelet, Charles ; Dériaz, Olivier ; Golay, Alain ; Witztum, Joseph L ; Giacobino, Jean-Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5395-c122d1ebe19cfef76ea7c1b9cb405af3e199720180cf444ed2b8bffdfb4046dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>4-HNE, 4-hydroxynonenal</topic><topic>4-Hydroxynonenal</topic><topic>Adult</topic><topic>Aldehydes - analysis</topic><topic>Endurance training</topic><topic>ET, endurance-trained</topic><topic>Humans</topic><topic>IMTG, intra-myocellular triglycerides</topic><topic>Intra-myocellular triglyceride</topic><topic>Lipid Peroxidation</topic><topic>Lipids - classification</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>ORO, Oil red oil</topic><topic>Physical Endurance</topic><topic>Triglycerides - analysis</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russell, Aaron P</creatorcontrib><creatorcontrib>Gastaldi, Giacomo</creatorcontrib><creatorcontrib>Bobbioni-Harsch, Elisabetta</creatorcontrib><creatorcontrib>Arboit, Patrizia</creatorcontrib><creatorcontrib>Gobelet, Charles</creatorcontrib><creatorcontrib>Dériaz, Olivier</creatorcontrib><creatorcontrib>Golay, Alain</creatorcontrib><creatorcontrib>Witztum, Joseph L</creatorcontrib><creatorcontrib>Giacobino, Jean-Paul</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russell, Aaron P</au><au>Gastaldi, Giacomo</au><au>Bobbioni-Harsch, Elisabetta</au><au>Arboit, Patrizia</au><au>Gobelet, Charles</au><au>Dériaz, Olivier</au><au>Golay, Alain</au><au>Witztum, Joseph L</au><au>Giacobino, Jean-Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2003-09-11</date><risdate>2003</risdate><volume>551</volume><issue>1</issue><spage>104</spage><epage>106</epage><pages>104-106</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>12965212</pmid><doi>10.1016/S0014-5793(03)00875-5</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 2003-09, Vol.551 (1), p.104-106 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | ScienceDirect; Wiley-Blackwell Read & Publish Collection |
| subjects | 4-HNE, 4-hydroxynonenal 4-Hydroxynonenal Adult Aldehydes - analysis Endurance training ET, endurance-trained Humans IMTG, intra-myocellular triglycerides Intra-myocellular triglyceride Lipid Peroxidation Lipids - classification Male Middle Aged Muscle Muscle, Skeletal - chemistry Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Obesity Obesity - metabolism ORO, Oil red oil Physical Endurance Triglycerides - analysis Triglycerides - metabolism |
| title | Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? |
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