Tomographic optical breast imaging guided by three-dimensional mammography

We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spa...

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Bibliographic Details
Published in:Applied optics (2004) 2003-09, Vol.42 (25), p.5181-5190
Main Authors: Li, Ang, Miller, Eric L, Kilmer, Misha E, Brukilacchio, Thomas J, Chaves, Tina, Stott, Jonathan, Zhang, Quan, Wu, Tao, Chorlton, MaryAnn, Moore, Richard H, Kopans, Daniel B, Boas, David A
Format: Article
Language:English
Subjects:
Breast
Computer Simulation
Female
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Mammography
Models, Theoretical
Optics and Photonics
Tomography
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Summary:We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.
ISSN:1559-128X
DOI:10.1364/AO.42.005181