Oxidative stress‐related increase in ubiquitination in early coronary atherogenesis

ABSTRACT The ubiquitin‐proteasome system (UPS) is involved in the removal of damaged proteins and the activation of transcription factors, such as nuclear‐factor‐κB. Recent reports, however, questioned the functional activity of the UPS under conditions of increased oxidative stress, such as experim...

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Published in:The FASEB journal 2003-09, Vol.17 (12), p.1730-1732
Main Authors: Herrmann, Joerg, Gulati, Rajiv, Napoli, Claudio, Woodrum, Julie E., Lerman, Lilach O., Rodriguez-Porcel, Martin, Sica, Vincenzo, Simari, Robert D., Ciechanover, Aaron, Lerman, Amir
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
coronary artery disease
Coronary Artery Disease - etiology
Coronary Artery Disease - metabolism
Coronary Vessels - metabolism
Cysteine Endopeptidases - metabolism
Female
Hypercholesterolemia - metabolism
Models, Biological
Multienzyme Complexes - metabolism
Muscle, Smooth, Vascular - metabolism
Oxidative Stress
proteasome
Proteasome Endopeptidase Complex
Proteins - metabolism
Swine
ubiquitin
Ubiquitins - metabolism
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Summary:ABSTRACT The ubiquitin‐proteasome system (UPS) is involved in the removal of damaged proteins and the activation of transcription factors, such as nuclear‐factor‐κB. Recent reports, however, questioned the functional activity of the UPS under conditions of increased oxidative stress, such as experimental hypercholesterolemia, which was the objective of our study. Pigs were placed on a normal chow diet (N) or on a hypercholesterolemic diet without (HC) or with vitamin C and E supplementation (HC+VIT) for 12 weeks. Compared with N, plasma concentration of total cholesterol increased in both HC and HC+VIT [76 ± 21 vs. 400 ± 148 (P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.02-0841fje