Treatment of Helicobacter Pylori Infection Using a Novel Antiadhesion Compound (3′sialyllactose sodium salt). A Double blind, Placebo-Controlled Clinical Study

ABSTRACT Background and Aim. 3′ sialyllactose sodium salt (3′SL) is an oligosaccharide that occurs naturally in human and bovine milk. It can inhibit the adhesion of H. pylori to human epithelial cells in vitro. The aim of this study was to test whether this oligosaccharide can suppress or cure H. p...

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Published in:Helicobacter (Cambridge, Mass.) Mass.), 2003-08, Vol.8 (4), p.252-256
Main Authors: Parente, F., Cucino, C., Anderloni, A., Grandinetti, G., Porro, G. Bianchi
Format: Article
Language:English
Subjects:
13C-urea breath test
3′ sialyllactose sodium salt
Adult
antiadhesive therapy
Bacterial Adhesion - drug effects
Breath Tests
Double-Blind Method
Dyspepsia - drug therapy
Dyspepsia - microbiology
Female
Helicobacter Infections - drug therapy
Helicobacter pylori - drug effects
Helicobacter pylori infection
Humans
Male
Middle Aged
Oligosaccharides - administration & dosage
Oligosaccharides - therapeutic use
Urea - metabolism
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Summary:ABSTRACT Background and Aim. 3′ sialyllactose sodium salt (3′SL) is an oligosaccharide that occurs naturally in human and bovine milk. It can inhibit the adhesion of H. pylori to human epithelial cells in vitro. The aim of this study was to test whether this oligosaccharide can suppress or cure H. pylori colonization in vivo and to determine its safety in humans. Methods. Seventy‐one consecutive dyspeptic patients with H. pylori infection documented by histology and 13C‐Urea Breath Test (UBT) were initially recruited to this study. Patients with UBT values
ISSN:1083-4389
1523-5378
DOI:10.1046/j.1523-5378.2003.00152.x