Endotoxin inhibition of luteinizing hormone in sheep

Administration of endotoxin suppresses circulating concentration of luteinizing hormone (LH) in a number of species, including rats, sheep, cattle, and non-human primates. Specifically, endotoxin administration decreases circulating concentration of LH and LH pulses frequency in castrated male sheep...

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Bibliographic Details
Published in:Domestic animal endocrinology 2003-07, Vol.25 (1), p.13-19
Main Authors: Daniel, J.A., Abrams, M.S., deSouza, L., Wagner, C.G., Whitlock, B.K., Sartin, J.L.
Format: Article
Language:English
Subjects:
adverse effects
Animals
Endotoxin
endotoxin mediators
endotoxins
Endotoxins - pharmacology
gonadotropin release
gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone - physiology
hormone secretion
hypothalamic regulation
hypothalamus
Hypothalamus - drug effects
immune response
inflammation
LH inhibition
luteinizing hormone
Luteinizing Hormone - antagonists & inhibitors
Luteinizing Hormone - blood
Luteinizing Hormone - secretion
Male
mechanism of action
Orchiectomy
pituitary gland
Pituitary Gland - drug effects
Sheep
site of action
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Summary:Administration of endotoxin suppresses circulating concentration of luteinizing hormone (LH) in a number of species, including rats, sheep, cattle, and non-human primates. Specifically, endotoxin administration decreases circulating concentration of LH and LH pulses frequency in castrated male sheep. Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH. The site of endotoxin suppression of circulating concentrations of LH as well as possible mediators of endotoxin suppression of circulating concentrations of LH, including cortiocotropin-releasing hormone, arginine vasopressin, glucocorticoids, inflammatory cytokines, prostaglandins, and opioids, are discussed.
ISSN:0739-7240
1879-0054
DOI:10.1016/S0739-7240(03)00042-0