Heart Imaging with Cationic Complexes of Technetium

The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-10, Vol.214 (4516), p.85-86
Main Authors: Deutsch, Edward, Bushong, William, Glavan, Kenneth A., Elder, R. C., Sodd, Vincent J., Scholz, Kenneth L., Fortman, Donald L., Lukes, Steven J.
Format: Article
Language:English
Subjects:
Animals
Birds
Blood
Cations, Monovalent
Dogs
Gamma rays
Heart
Heart - diagnostic imaging
Imaging
Ligands
Liver
Myocardium
Nuclear medicine
Organotechnetium Compounds
Phosphines
Radionuclide Imaging
Structure-Activity Relationship
Technetium
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Summary:The cationic technetium-99 complex trans-[$^{99}$TC(dmpe)$_{2}$Cl$_{2}$]$^{+}$, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH$_{3}$)$_{2}$P-CH$_{2}$CH$_{2}$-P(CH$_{3}$)$_{2}$, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-[$^{99\text{m}}$Tc(dmpe) $_{2}$Cl$_{2}$]$^{+}$, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6897930