Comparison of C0 and C2 cyclosporine monitoring in long-term renal transplant recipients

• Published in: Transplantation proceedings 2003-08, Vol.35 (5), p.1780-1782
• Main Authors: Marcén, R, Pascual, J, Tato, A, Villafruela, J.J, Teruel, J.L, Rivera, M.E, Tenorio, M, Fernández, M, Burgos, F.J, Ortuño, J
• Format: Article
• Language: English
• Subjects: Azathioprine - therapeutic use; Biological and medical sciences; Creatinine - blood; Cyclosporine - blood; Cyclosporine - pharmacokinetics; Cyclosporine - therapeutic use; Drug Monitoring - methods; Drug Therapy, Combination; Emulsions; Humans; Immunomodulators; Immunosuppressive Agents - blood; Immunosuppressive Agents - pharmacokinetics; Immunosuppressive Agents - therapeutic use; Kidney Transplantation - immunology; Medical sciences; Metabolic Clearance Rate; Mycophenolic Acid - analogs & derivatives; Mycophenolic Acid - therapeutic use; Pharmacology. Drug treatments; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/S0041-1345(03)00579-7

Recent data show that monitoring cyclosporine A (CsA) concentrations with 2-hour postdose levels (C2) correlates with the incidence of rejection and graft outcome in de novo renal transplant patients. The purpose of the present work was to evaluate the advantage of C2 monitoring after the first year of kidney transplantation. We studied 161 patients, 96 on CsA-prednisone and 65 on triple therapy (Aza or MMF) who had been transplanted for a mean of 103 ± 44 months. Mean serum creatinine (SCr) was 1.65 ± 0.69 mg/dL, mean C0 was 174 ± 44, and C2 was 667 ± 194 ng/mL. Patients were classified according to C2 values: >850 ( n = 29), between 850 and 450 ( n = 109), and