Evidence for Early Membrane Antigens in Cytomegalovirus-infected Cells

1 Department of Virology, Cancer Research Institute Kanazawa University, Kanazawa 920, Japan 2 Department of Obstetrics and Gynecology Ishikawa Prefectural Central Hospital, Kanazawa 920-02, Japan Human cytomegalovirus (HCMV) induces membrane antigens (MA) which are detectable by immunofluorescent t...

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Bibliographic Details
Published in:Journal of general virology 1981-03, Vol.53 (1), p.157-161
Main Authors: Tanaka, Junji, Yabuki, Yoshihiko, Hatano, Motoichi
Format: Article
Language:English
Subjects:
Animals
Antigens, Surface - analysis
Antigens, Viral - analysis
Cell Line
Cytarabine - pharmacology
Cytomegalovirus - growth & development
Cytomegalovirus - immunology
Dactinomycin - pharmacology
Humans
Puromycin - pharmacology
Time Factors
Viral Proteins - biosynthesis
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Summary:1 Department of Virology, Cancer Research Institute Kanazawa University, Kanazawa 920, Japan 2 Department of Obstetrics and Gynecology Ishikawa Prefectural Central Hospital, Kanazawa 920-02, Japan Human cytomegalovirus (HCMV) induces membrane antigens (MA) which are detectable by immunofluorescent techniques as early as 24 h after infection. These antigens appear on the surface of infected cells in non-permissive human epithelioid and animal cells in addition to permissive human cells. The synthesis of the MA occurs in the presence of a DNA synthesis inhibitor, whereas RNA and protein synthesis inhibitors prevent its formation completely. These results demonstrate that the MA is a newly synthesized protein coded by an early function of the viral genome. Received 19 July 1980; accepted 6 October 1980.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-53-1-157