Global impairment of cardiac autonomic nervous activity late after the Fontan operation

Atrial tachyarrhythmia is a common cause of morbidity and mortality in patients with univentricular physiology undergoing the Fontan operation. We examined cardiac autonomic nervous activity, a predictor of arrhythmia and sudden death in other cardiovascular disease, in patients late after the Fonta...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-09, Vol.108 (10), p.180-185
Main Authors: DAVOS, Constantinos H, FRANCIS, Darrel P, GATZOULIS, Michael A, LEENARTS, Marjolein F. E, YAP, Sing-Chien, WEI LI, DAVLOUROS, Periklis A, WENSEL, Roland, COATS, Andrew J. S, PIEPOLI, Massimo, SREERAM, Narayanswami
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autonomic Nervous System - physiopathology
Baroreflex
Biological and medical sciences
Child
Female
Fontan Procedure
Heart - innervation
Heart Defects, Congenital - complications
Heart Defects, Congenital - diagnosis
Heart Defects, Congenital - physiopathology
Heart Defects, Congenital - surgery
Heart Rate
Humans
Male
Medical sciences
Prospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Sympathetic Nervous System - physiopathology
Tachycardia - etiology
Vagus Nerve - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atrial tachyarrhythmia is a common cause of morbidity and mortality in patients with univentricular physiology undergoing the Fontan operation. We examined cardiac autonomic nervous activity, a predictor of arrhythmia and sudden death in other cardiovascular disease, in patients late after the Fontan operation, employing heart rate variability (HRV) and baroreflex sensitivity. We measured HRV and baroreflex sensitivity in 22 consecutive patients (8 male, age 26+/-9 years) who had undergone the Fontan operation 13+/-6 years previously, and 22 age- and sex-matched healthy controls. Fontan patients had significantly lower HRV (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.0000087946.47069.cb