A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?

The aim of this new meta-analysis (to the end of 2002) is to compile the Y allele frequencies of the C282Y mutation of hereditary hemochromatosis ( HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of C282Y frequencies...

Full description

Saved in:
Bibliographic Details
Published in:Blood cells, molecules, & diseases molecules, & diseases, 2003-09, Vol.31 (2), p.262-267
Main Authors: Lucotte, Gérard, Dieterlen, Florent
Format: Article
Language:English
Subjects:
C282Y allele map
C282Y frequencies
C282Y mutation
Celtic and Viking origins
Cysteine - genetics
Europe - ethnology
Female
Gene Frequency
Genetic Predisposition to Disease
Genetics, Population
Genotype
Hemochromatosis
Hemochromatosis - ethnology
Hemochromatosis - genetics
Hemochromatosis Protein
HFE gene
Histocompatibility Antigens Class I - genetics
Humans
Male
Membrane Proteins - genetics
Point Mutation
Populations in Europe
Tyrosine - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this new meta-analysis (to the end of 2002) is to compile the Y allele frequencies of the C282Y mutation of hereditary hemochromatosis ( HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia.
ISSN:1079-9796
1096-0961
DOI:10.1016/S1079-9796(03)00133-5