Loading…
A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?
The aim of this new meta-analysis (to the end of 2002) is to compile the Y allele frequencies of the C282Y mutation of hereditary hemochromatosis ( HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of C282Y frequencies...
Saved in:
| Published in: | Blood cells, molecules, & diseases molecules, & diseases, 2003-09, Vol.31 (2), p.262-267 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c361t-12226773584c33ca9f3f517330404b59989e1be87c0d92edd391d16e9d8d35f3 |
|---|---|
| cites | |
| container_end_page | 267 |
| container_issue | 2 |
| container_start_page | 262 |
| container_title | Blood cells, molecules, & diseases |
| container_volume | 31 |
| creator | Lucotte, Gérard Dieterlen, Florent |
| description | The aim of this new meta-analysis (to the end of 2002) is to compile the
Y allele frequencies of the
C282Y mutation of hereditary hemochromatosis (
HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of
C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia. |
| doi_str_mv | 10.1016/S1079-9796(03)00133-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73652780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1079979603001335</els_id><sourcerecordid>73652780</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-12226773584c33ca9f3f517330404b59989e1be87c0d92edd391d16e9d8d35f3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMoflR_gpKT6GE1H81m46WU4hcUPFgETyFNZm10d1OTXcF_79a2ePQQJgzPO8M8CJ1SckUJza-fKZEqU1LlF4RfEkI5z8QOOqRE5Vn_6O7qv0EO0FFK76SnqCr20QFlSjLCxSGqxvi2i2EJpsGmqqACXJslDiVuF4AnrGCvuO5a0_rQrLoLqINdxFCbNiSfbvAEqtZb_AUxdQm_-A_fvOEQ_ZtvtlO2-dEx2itNleBkUwdodnc7mzxk06f7x8l4mlme0zajjLFcSi6KoeXcGlXyUlDJORmS4VwoVSigcyikJU4xcI4r6mgOyhWOi5IP0Pl67DKGzw5Sq2ufLFSVaSB0SUueCyYL0oNiDdoYUopQ6mX0tYnfmhK9sqx_LeuVQk24_rWsRZ872yzo5jW4v9RGaw-M1gD0V355iDpZD40F5yPYVrvg_1nxAxbWi44</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73652780</pqid></control><display><type>article</type><title>A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?</title><source>Elsevier</source><creator>Lucotte, Gérard ; Dieterlen, Florent</creator><creatorcontrib>Lucotte, Gérard ; Dieterlen, Florent</creatorcontrib><description>The aim of this new meta-analysis (to the end of 2002) is to compile the
Y allele frequencies of the
C282Y mutation of hereditary hemochromatosis (
HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of
C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia.</description><identifier>ISSN: 1079-9796</identifier><identifier>EISSN: 1096-0961</identifier><identifier>DOI: 10.1016/S1079-9796(03)00133-5</identifier><identifier>PMID: 12972035</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>C282Y allele map ; C282Y frequencies ; C282Y mutation ; Celtic and Viking origins ; Cysteine - genetics ; Europe - ethnology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genetics, Population ; Genotype ; Hemochromatosis ; Hemochromatosis - ethnology ; Hemochromatosis - genetics ; Hemochromatosis Protein ; HFE gene ; Histocompatibility Antigens Class I - genetics ; Humans ; Male ; Membrane Proteins - genetics ; Point Mutation ; Populations in Europe ; Tyrosine - genetics</subject><ispartof>Blood cells, molecules, & diseases, 2003-09, Vol.31 (2), p.262-267</ispartof><rights>2003 Elsevier Science (USA)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-12226773584c33ca9f3f517330404b59989e1be87c0d92edd391d16e9d8d35f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12972035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucotte, Gérard</creatorcontrib><creatorcontrib>Dieterlen, Florent</creatorcontrib><title>A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?</title><title>Blood cells, molecules, & diseases</title><addtitle>Blood Cells Mol Dis</addtitle><description>The aim of this new meta-analysis (to the end of 2002) is to compile the
Y allele frequencies of the
C282Y mutation of hereditary hemochromatosis (
HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of
C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia.</description><subject>C282Y allele map</subject><subject>C282Y frequencies</subject><subject>C282Y mutation</subject><subject>Celtic and Viking origins</subject><subject>Cysteine - genetics</subject><subject>Europe - ethnology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Hemochromatosis</subject><subject>Hemochromatosis - ethnology</subject><subject>Hemochromatosis - genetics</subject><subject>Hemochromatosis Protein</subject><subject>HFE gene</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Point Mutation</subject><subject>Populations in Europe</subject><subject>Tyrosine - genetics</subject><issn>1079-9796</issn><issn>1096-0961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMoflR_gpKT6GE1H81m46WU4hcUPFgETyFNZm10d1OTXcF_79a2ePQQJgzPO8M8CJ1SckUJza-fKZEqU1LlF4RfEkI5z8QOOqRE5Vn_6O7qv0EO0FFK76SnqCr20QFlSjLCxSGqxvi2i2EJpsGmqqACXJslDiVuF4AnrGCvuO5a0_rQrLoLqINdxFCbNiSfbvAEqtZb_AUxdQm_-A_fvOEQ_ZtvtlO2-dEx2itNleBkUwdodnc7mzxk06f7x8l4mlme0zajjLFcSi6KoeXcGlXyUlDJORmS4VwoVSigcyikJU4xcI4r6mgOyhWOi5IP0Pl67DKGzw5Sq2ufLFSVaSB0SUueCyYL0oNiDdoYUopQ6mX0tYnfmhK9sqx_LeuVQk24_rWsRZ872yzo5jW4v9RGaw-M1gD0V355iDpZD40F5yPYVrvg_1nxAxbWi44</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Lucotte, Gérard</creator><creator>Dieterlen, Florent</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?</title><author>Lucotte, Gérard ; Dieterlen, Florent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-12226773584c33ca9f3f517330404b59989e1be87c0d92edd391d16e9d8d35f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>C282Y allele map</topic><topic>C282Y frequencies</topic><topic>C282Y mutation</topic><topic>Celtic and Viking origins</topic><topic>Cysteine - genetics</topic><topic>Europe - ethnology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Hemochromatosis</topic><topic>Hemochromatosis - ethnology</topic><topic>Hemochromatosis - genetics</topic><topic>Hemochromatosis Protein</topic><topic>HFE gene</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Point Mutation</topic><topic>Populations in Europe</topic><topic>Tyrosine - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucotte, Gérard</creatorcontrib><creatorcontrib>Dieterlen, Florent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood cells, molecules, & diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucotte, Gérard</au><au>Dieterlen, Florent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?</atitle><jtitle>Blood cells, molecules, & diseases</jtitle><addtitle>Blood Cells Mol Dis</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>31</volume><issue>2</issue><spage>262</spage><epage>267</epage><pages>262-267</pages><issn>1079-9796</issn><eissn>1096-0961</eissn><abstract>The aim of this new meta-analysis (to the end of 2002) is to compile the
Y allele frequencies of the
C282Y mutation of hereditary hemochromatosis (
HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of
C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12972035</pmid><doi>10.1016/S1079-9796(03)00133-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-9796 |
| ispartof | Blood cells, molecules, & diseases, 2003-09, Vol.31 (2), p.262-267 |
| issn | 1079-9796 1096-0961 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73652780 |
| source | Elsevier |
| subjects | C282Y allele map C282Y frequencies C282Y mutation Celtic and Viking origins Cysteine - genetics Europe - ethnology Female Gene Frequency Genetic Predisposition to Disease Genetics, Population Genotype Hemochromatosis Hemochromatosis - ethnology Hemochromatosis - genetics Hemochromatosis Protein HFE gene Histocompatibility Antigens Class I - genetics Humans Male Membrane Proteins - genetics Point Mutation Populations in Europe Tyrosine - genetics |
| title | A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation? |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T11%3A34%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20European%20allele%20map%20of%20the%20C282Y%20mutation%20of%20hemochromatosis:%20Celtic%20versus%20Viking%20origin%20of%20the%20mutation?&rft.jtitle=Blood%20cells,%20molecules,%20&%20diseases&rft.au=Lucotte,%20G%C3%A9rard&rft.date=2003-09-01&rft.volume=31&rft.issue=2&rft.spage=262&rft.epage=267&rft.pages=262-267&rft.issn=1079-9796&rft.eissn=1096-0961&rft_id=info:doi/10.1016/S1079-9796(03)00133-5&rft_dat=%3Cproquest_cross%3E73652780%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c361t-12226773584c33ca9f3f517330404b59989e1be87c0d92edd391d16e9d8d35f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=73652780&rft_id=info:pmid/12972035&rfr_iscdi=true |