Effect of lithium and sodium ions on opiate- and dopamine-receptor binding

The effects of lithium and sodium were studied in the corpus striatum and cerebral cortex of rats. Lithium was inhibitory at low concentrations but at 20 mM it increased the binding of [G-3H]naloxone (specific activity 15.6 Ci/mmol). Sodium stimulated the high-affinity binding of this compound. Memb...

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Bibliographic Details
Published in:Neurochemical research 1981-03, Vol.6 (3), p.321-331
Main Authors: Wajda, I J, Banay-Schwartz, M, Manigault, I, Lajtha, A
Format: Article
Language:English
Subjects:
Animals
brain
Cerebral Cortex - metabolism
Corpus Striatum - metabolism
Dihydromorphine - metabolism
dopamine
Enkephalin, Leucine-2-Alanine - analogs & derivatives
Enkephalins - metabolism
lithium
Lithium - pharmacology
Naloxone - metabolism
opiates
Rats
Receptors, Dopamine - metabolism
Receptors, Opioid - metabolism
sodium
Sodium - pharmacology
Spiperone - metabolism
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Summary:The effects of lithium and sodium were studied in the corpus striatum and cerebral cortex of rats. Lithium was inhibitory at low concentrations but at 20 mM it increased the binding of [G-3H]naloxone (specific activity 15.6 Ci/mmol). Sodium stimulated the high-affinity binding of this compound. Membranes obtained from the rats treated with lithium showed lower specific binding of both [3H]naloxone and [3H]DHM. Binding of [3H]d-alanine Leu-enkephalin was not changed in the brains of lithium-treated rats, but that of [3H]-spiroperidol was lowered. Cerebral cortex and striatum of lithium-treated rats had a decreased apparent dissociation constant and a lower receptor concentration of naloxone binding sites.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00964047