Clinical significance of serum RCAS1 levels detected by monoclonal antibody 22-1-1 in patients with cholangiocellular carcinoma

Background/Aims : The tumor-associated antigen, RCAS1, has been reported to be expressed in various types of cancer, including cholangiocarcinoma. We measured serum RCAS1 levels in patients with intrahepatic cholangiocellular carcinoma (CCC) and other hepatobiliary diseases, and examined the clinica...

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Published in:Journal of hepatology 2003-10, Vol.39 (4), p.559-563
Main Authors: Watanabe, Hironobu, Enjoji, Munechika, Nakashima, Manabu, Noguchi, Ken-ichi, Kinukawa, Naoko, Sugimoto, Rie, Kotoh, Kazuhiro, Nakamuta, Makoto, Nawata, Hajime, Watanabe, Takeshi
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Monoclonal
Antigens, Neoplasm - blood
Bile Duct Neoplasms - blood
Bile Duct Neoplasms - immunology
Bile Duct Neoplasms - surgery
Bile Ducts, Intrahepatic - surgery
Biological and medical sciences
CA-19-9 Antigen - blood
CA19-9
Carcinoembryonic Antigen - blood
Cholangiocarcinoma - blood
Cholangiocarcinoma - immunology
Cholangiocarcinoma - surgery
Cholangiocellular carcinoma
Enzyme-Linked Immunosorbent Assay
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Postoperative Period
RCAS1
Tumor marker
Tumors
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Summary:Background/Aims : The tumor-associated antigen, RCAS1, has been reported to be expressed in various types of cancer, including cholangiocarcinoma. We measured serum RCAS1 levels in patients with intrahepatic cholangiocellular carcinoma (CCC) and other hepatobiliary diseases, and examined the clinical significance of serum RCAS1 as a tumor marker. Methods : Sera collected from the patients and healthy volunteers were used for ELISA for RCAS1. The values of RCAS1 for CCC patients were compared to those of other tumor marker proteins. Results : Serum RCAS1 levels exceeded the normal limit in a high percentage (73.9%) of CCC patients. The positivity rate was higher than those of CA19-9 and CEA. No correlation was found between the RCAS1 and CA19-9 concentrations. Serum RCAS1 was positive in many cases that were negative for CA19-9. Surgical resection of CCC reduced the RCAS1 level to within the normal range. On the other hand, serum RCAS1 levels were elevated in very few cases of benign hepatobiliary disease. Conclusions : As a tumor marker in CCC, RCAS1 is, at least, of complementary value to CA19-9 and CEA. Measuring serum RCAS1 contributes to the diagnostic accuracy, and is useful for estimating tumor progression or therapeutic effect.
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(03)00363-5