8-methoxypsoralen and the eye

The kinetics of migration of radiolabeled 8-methoxypsoralen into human cataract lenses were investigated in 12 patients undergoing operation. Lenses were examined from 2.5 - 72 h after intake of 3H-labeled 8-methoxypsoralen by mouth. Demonstrable amounts of activity was only found in two of three le...

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Bibliographic Details
Published in:Archives of Dermatological Research 1981-01, Vol.270 (4), p.387-390
Main Authors: Marqversen, J, Axelsen, I, Nielsen, E, Zachariae, H
Format: Article
Language:English
Subjects:
Aged
Aqueous Humor - metabolism
Cataract - blood
Cataract - metabolism
Cataract Extraction
Humans
Methoxsalen - blood
Methoxsalen - metabolism
Middle Aged
Tritium
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Summary:The kinetics of migration of radiolabeled 8-methoxypsoralen into human cataract lenses were investigated in 12 patients undergoing operation. Lenses were examined from 2.5 - 72 h after intake of 3H-labeled 8-methoxypsoralen by mouth. Demonstrable amounts of activity was only found in two of three lenses studied 24 h after intake. The aqueous humor contained less 8-methoxypsoralen than serum. The results of the study may add support to the opinion that a less rigorous sunglass regimen than that recommended by certain PUVA centers may be justified.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00403782