Growth signalling pathways in Arabidopsis and the AGC protein kinases

• Published in: Trends in plant science 2003-09, Vol.8 (9), p.424-431
• Main Authors: Bögre, László, Ökrész, László, Henriques, Rossana, Anthony, Richard G.
• Format: Article
• Language: English
• Subjects: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Arabidopsis - classification; Arabidopsis - enzymology; Arabidopsis - growth & development; Binding Sites; Biological and medical sciences; Cell physiology; Cyclic AMP-Dependent Protein Kinases - chemistry; Cyclic AMP-Dependent Protein Kinases - metabolism; Fundamental and applied biological sciences. Psychology; Molecular and cellular biology; Peptide Fragments - chemistry; Phylogeny; Plant growth. Development of the storage organs; Plant physiology and development; Protein Kinases - chemistry; Protein Kinases - metabolism; Protein Serine-Threonine Kinases - metabolism; Signal transduction; Signal Transduction - physiology; Vegetative apparatus, growth and morphogenesis. Senescence
• ISSN: 1360-1385; 1878-4372
• DOI: 10.1016/S1360-1385(03)00188-2

Lipid-derived signals are central to regulating a multitude of cellular processes but, in plants, little is known of the downstream signalling pathways. The Arabidopsis 3-phosphoinositide-dependent protein kinase (PDK1) could couple lipid signals to the activation of several protein kinases of the so-called AGC kinase family. The Arabidopsis AGC kinases contain sequence motives required for the docking of PDK1 and phosphorylation of their activation loop in the kinase catalytic domain. It is becoming evident that specific members of the AGC kinases are implicated in key growth signalling pathways. For example, Arabidopsis p70 S6K might be a nodal point able to integrate hormonal and developmental signals with nutritional inputs, together with the Arabidopsis Target of Rapamycin (TOR) protein.