Patterns of regeneration in vessels of human diseased muscle and skin. An ultrastructural study

Regenerating vessels from 36 muscle biopsies and 12 skin biopsies pertaining to patients with the clinical and histological diagnosis of dermatomyositis-polymyositis and other inflammatory myopathies were described ultrastructurally. The following characteristics of vascular regeneration were encoun...

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Bibliographic Details
Published in:Virchows Archiv. Abteilung B. Zellpathologie 1981-01, Vol.36 (1), p.65-75
Main Author: Ludatscher, R M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Blood Vessels - ultrastructure
Child
Child, Preschool
Dermatomyositis - pathology
Humans
Microscopy, Electron
Middle Aged
Muscles - blood supply
Muscles - pathology
Muscles - ultrastructure
Muscular Diseases - pathology
Regeneration
Skin - blood supply
Skin - pathology
Skin - ultrastructure
Skin Diseases - pathology
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Summary:Regenerating vessels from 36 muscle biopsies and 12 skin biopsies pertaining to patients with the clinical and histological diagnosis of dermatomyositis-polymyositis and other inflammatory myopathies were described ultrastructurally. The following characteristics of vascular regeneration were encountered: a) alternation of thin and thick endothelial cells, b) superimposed segments of endothelial cytoplasm with formation of twisted intercellular junctions, c) long and complex intraluminal endothelial projections, d) discontinuous and porous perivascular basement lamina or multilaminated basement lamina. Some vessels featured only two or three of the mentioned characteristics. Endothelial fenestrations were occasionally encountered in the skin capillaries and were an exception in the muscle capillaries. In the skin there were aspects suggesting that intercalation of perivascular cells in the regenerating endothelial wall may occur. Most capillaries were in the final stage of regeneration.
ISSN:0340-6075
0042-6431
DOI:10.1007/BF02912056