Effects of exercise training on conduit and resistance vessel function in treated and untreated hypercholesterolaemic subjects

Aims Despite the importance of both lipid metabolism and physical activity to cardiovascular health, few studies have examined the effect of exercise training on vascular function in hypercholesterolaemic humans. Methods and results A randomized, cross-over design investigated the effect of 8 weeks...

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Bibliographic Details
Published in:European heart journal 2003-09, Vol.24 (18), p.1681-1689
Main Authors: Walsh, Jennifer H., Yong, Gerald, Cheetham, Craig, Watts, Gerald F., O’Driscoll, Gerard J., Taylor, Roger R., Green, Daniel J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood flow
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Over Studies
Disorders of blood lipids. Hyperlipoproteinemia
Endothelial function
Endothelium, Vascular - physiology
Exercise
Exercise Therapy
Female
Forearm - blood supply
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypercholesterolemia - drug therapy
Hypercholesterolemia - physiopathology
Hypercholesterolemia - rehabilitation
Male
Medical sciences
Metabolic diseases
Middle Aged
Nitric oxide
Plethysmography
Ultrasound
Vascular Resistance - physiology
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Summary:Aims Despite the importance of both lipid metabolism and physical activity to cardiovascular health, few studies have examined the effect of exercise training on vascular function in hypercholesterolaemic humans. Methods and results A randomized, cross-over design investigated the effect of 8 weeks of combined aerobic and resistance exercise training on conduit and resistance vessel function in 11 untreated subjects with hypercholesterolaemia and 11 subjects taking lipid-lowering medication. High-resolution vascular ultrasonography following forearm ischaemia and glyceryl trinitrate administration determined conduit vessel endothelium-dependent and independent function. Strain-gauge plethysmography, with intra-aerial infusions of acetylcholine, sodium nitroprusside and NG-monomethyl-L-arginine, determined resistance vessel function. Flow-mediated dilation and the forearm blood flow response to acetylcholine improved significantly following training in the treated subgroup (both P
ISSN:0195-668X
1522-9645
DOI:10.1016/S0195-668X(03)00384-1