Second trimester total human chorionic gonadotropin, alpha-fetoprotein and unconjugated estriol in predicting pregnancy complications other than fetal aneuploidy

• Published in: European journal of obstetrics & gynecology and reproductive biology 2003-09, Vol.110 (1), p.12-15
• Main Authors: Duric, Koraljka, Skrablin, Snjezana, Lesin, Josko, Kalafatic, Drzislav, Kuvacic, Ivan, Suchanek, Ernest
• Format: Article
• Language: English
• Subjects: Abortion, Spontaneous - diagnosis; Adult; Alpha-fetoprotein; alpha-Fetoproteins - analysis; Aneuploidy; Biological and medical sciences; Chorionic Gonadotropin - blood; Down Syndrome - diagnosis; Estriol - blood; Female; Fetal Death - diagnosis; Fetal Growth Retardation - diagnosis; Gynecology. Andrology. Obstetrics; Human chorionic gonadotropin; Humans; Management. Prenatal diagnosis; Medical sciences; Neural Tube Defects - diagnosis; Obstetric Labor, Premature - diagnosis; Odds Ratio; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy. Fetus. Placenta; Prenatal Diagnosis - methods; Unconjugated estriol
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/S0301-2115(03)00081-2

Objective: To assess the value of alpha-fetoprotein (AFP), total human chorionic gonadotropin (ThCG) and unconjugated estriol in predicting certain complications of pregnancy other than fetal aneuploidy. Study design: Among 2384 women that underwent biochemical screening between 15 and 22 weeks of gestation, pregnancy outcome was evaluated in 677 women under 35 years of age according to serum marker levels by using cut-off points discriminative for Down syndrome or neural tube defect (NTD). Results: High alpha-fetoprotein levels (MoM≥2.0) were found to be significantly more frequent ( P