Accuracy of frozen section examination of pelvic lymph nodes in patients with FIGO stage IB1 to IIB cervical cancer

We evaluated the accuracy of intraoperative frozen section histology of pelvic lymph nodes in patients with FIGO stage IB1 to IIB cervical cancer. A total of 96 patients with cervical cancer FIGO stage IB1 to IIB had surgery including systematic pelvic or pelvic and paraaortic lymphadenectomy and in...

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Bibliographic Details
Published in:Gynecologic oncology 2003-09, Vol.90 (3), p.605-609
Main Authors: Scholz, Heinz S., Lax, Sigurd F., Benedicic, Christoph, Tamussino, Karl, Winter, Raimund
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cervical cancer
Cervical carcinoma
Female
Female genital diseases
Frozen section
Frozen Sections
Genital system. Mammary gland
Gynecology. Andrology. Obstetrics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lymph Nodes - pathology
Lymph Nodes - surgery
Medical sciences
Middle Aged
Neoplasm Staging
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pelvic lymph nodes
Sensitivity and Specificity
Tumors
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
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Summary:We evaluated the accuracy of intraoperative frozen section histology of pelvic lymph nodes in patients with FIGO stage IB1 to IIB cervical cancer. A total of 96 patients with cervical cancer FIGO stage IB1 to IIB had surgery including systematic pelvic or pelvic and paraaortic lymphadenectomy and intraoperative frozen section examination of pelvic lymph nodes at our department between January 1997 and October 2001. The results of frozen section were compared with those of final histology. A total of 1044 pelvic lymph nodes underwent intraoperative frozen section examination and node metastases were found in 29 patients (30%). Final histopathology yielded a total of 5042 lymph nodes and identified an additional seven patients with node metastases for a false negative rate of 19%. The specificity and the positive predictive value of frozen section examination were 100%; the negative predictive value was 90% (60/67). The diagnostic accuracy of frozen section analysis of pelvic lymph nodes should be considered when intraoperative decisions are based on its results.
ISSN:0090-8258
1095-6859
DOI:10.1016/S0090-8258(03)00398-6