Experimental paracoccidioidomycosis in dogs

The aim of this study was to evaluate the susceptibility of dogs to develop paracoccidioidomycosis by experimental infection. Puppies were inoculated with Paracoccidioides brasiliensis by an intravenous route and two out of four died 1 week postinoculation, showing, at histopathological analysis, gr...

Full description

Saved in:
Bibliographic Details
Published in:Medical Mycology 2003-06, Vol.41 (3), p.265-268
Main Authors: Ono, M. A., Kishima, M. O., Itano, E. N., Bracarense, A. P. F. R. L., Camargo, Z. P.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - blood
Antigens, Fungal - immunology
Biological and medical sciences
Dog Diseases - microbiology
Dog Diseases - pathology
Dogs
Enzyme-Linked Immunosorbent Assay
Experimental mycoses and models
Female
Fungal Proteins - immunology
Glycoproteins - immunology
Infectious diseases
Liver - microbiology
Liver - pathology
Lung - microbiology
Lung - pathology
Male
Medical sciences
Mycoses
Paracoccidioides - isolation & purification
Paracoccidioides - pathogenicity
Paracoccidioides brasiliensis
Paracoccidioidomycosis - microbiology
Paracoccidioidomycosis - pathology
Paracoccidioidomycosis - veterinary
Spleen - microbiology
Spleen - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate the susceptibility of dogs to develop paracoccidioidomycosis by experimental infection. Puppies were inoculated with Paracoccidioides brasiliensis by an intravenous route and two out of four died 1 week postinoculation, showing, at histopathological analysis, granulomas in the lungs, spleen and liver. P. brasiliensis was isolated from these organs. The animals that survived the infection showed a strong reaction when skin was tested with gp43, a specific antigen of P. brasiliensis. These animals were killed at 1 and 5 months after infection, and no lesions, macroscopic or microscopic, were observed in the lungs, spleen or liver; furthermore no P. brasiliensis culture was obtained from these organs. These results suggest that dogs can develop paracoccidioidomycosis and reinforces the importance of this animal as a sensitive indicator of P. brasiliensis in the environment.
ISSN:1369-3786
1362-3095
1460-2709
DOI:10.1080/13693780310001597395