Linearized Reference Tissue Parametric Imaging Methods: Application to [ C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain

• Published in: Journal of cerebral blood flow and metabolism 2003-09, Vol.23 (9), p.1096-1112
• Main Authors: Ichise, Masanori, Liow, Jeih-San, Lu, Jian-Qiang, Takano, Akihiro, Model, Kendra, Toyama, Hiroshi, Suhara, Tetsuya, Suzuki, Kazutoshi, Innis, Robert B., Carson, Richard E.
• Format: Article
• Language: English
• Subjects: Aniline Compounds - chemistry; Aniline Compounds - metabolism; Biological and medical sciences; Brain - anatomy & histology; Brain - diagnostic imaging; Brain - metabolism; Carbon Radioisotopes - chemistry; Carbon Radioisotopes - metabolism; Carrier Proteins - metabolism; Diagnostic Imaging; Humans; Investigative techniques, diagnostic techniques (general aspects); Mathematics; Medical sciences; Membrane Glycoproteins - metabolism; Membrane Transport Proteins; Models, Biological; Nerve Tissue Proteins; Nervous system; Radionuclide investigations; Reference Standards; Serotonin Plasma Membrane Transport Proteins; Sulfides - chemistry; Sulfides - metabolism; Tomography, Emission-Computed - methods
• ISSN: 0271-678X; 1559-7016
• DOI: 10.1097/01.WCB.0000085441.37552.CA

The authors developed and applied two new linearized reference tissue models for parametric images of binding potential (BP) and relative delivery (R1) for [11C]DASB positron emission tomography imaging of serotonin transporters in human brain. The original multilinear reference tissue model (MRTMO) was modified (MRTM) and used to estimate a clearance rate (k′2) from the cerebellum (reference). Then, the number of parameters was reduced from three (MRTM) to two (MRTM2) by fixing k′2. The resulting BP and R1 estimates were compared with the corresponding nonlinear reference tissue models, SRTM and SRTM2, and one-tissue kinetic analysis (1TKA), for simulated and actual [11C]DASB data. MRTM gave k′2 estimates with little bias (