Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB

The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-infl...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2003-10, Vol.64 (3), p.765-771
Main Authors: Hwang, B.Y, Lee, J.H, Nam, J.B, Hong, Y.S, Lee, J.J
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
cell lines
chemical structure
Gene Expression Regulation - drug effects
Genes, Reporter - drug effects
Genes, Reporter - genetics
HeLa Cells
herbaceous plants
human health
Humans
lignans
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
Luciferases - genetics
manassantins
medicinal plants
NF-kappa B - antagonists & inhibitors
NF-kappa B - genetics
Nuclear Magnetic Resonance, Biomolecular
perennials
phytochemicals
plant extracts
Plant Roots - chemistry
roots
saucerneols
Saururaceae
Saururaceae - chemistry
Saururus
Saururus chinensis
sesquineolignans
spectral analysis
stereochemistry
Stereoisomerism
transcription factor NF-kappaB
transcription factors
Transfection
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Summary:The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity was studied using HeLa cells transfected with NF-kappaB reporter construct. All compounds except for (+)-saucernetin inhibited NF-kappaB dependent reporter gene expression with IC50 values of 2.5-16.9 microM.
ISSN:0031-9422
1873-3700