Endocrine responses to thyrotropin-releasing hormone in major depressive disorders

The endocrine response to thyrotropin-releasing hormone (TRH) was studied in severely endogenously depressed patients during illness (n=21) and after recovery (n=18). The thyroid-stimulating hormone (TSH) response to TRH was blunted (ΔTSH < 5 μIU/ml) in over one third of depressives during illnes...

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Bibliographic Details
Published in:Psychiatry research 1981-10, Vol.5 (2), p.205-215
Main Authors: Asnis, Gregory M., Sachar, Edward J., Halbreich, Uriel, Nathan, R.Swami, Ostrow, Lynn, Solomon, Murray, Halpern, Frieda S.
Format: Article
Language:English
Subjects:
Adult
Depressive Disorder - blood
Female
Growth Hormone - blood
Humans
Hydrocortisone - blood
Male
Middle Aged
Neurotransmitter Agents - metabolism
Prolactin - blood
Thyrotropin - blood
Thyrotropin-Releasing Hormone - blood
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Summary:The endocrine response to thyrotropin-releasing hormone (TRH) was studied in severely endogenously depressed patients during illness (n=21) and after recovery (n=18). The thyroid-stimulating hormone (TSH) response to TRH was blunted (ΔTSH < 5 μIU/ml) in over one third of depressives during illness and remained blunted in most even after recovery. There was no correlation between multiple measures of cortisol secretion (the mean 24-hour plasma cortisol, dexamethasone suppression test, and plasma cortisol during the TRH procedure) and the TSH response during illness and after recovery. The TSH and prolactin (PRL) responses to TRH, as well as the baseline PRL, were significantly lower during illness. The role of possible abnormalities in dopamine and/or serotonin in depression contributing to these endocrine disturbances is discussed.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(81)90050-0