Synthesis and structural study of two new heparin-like hexasaccharides

Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2003-01, Vol.1 (13), p.2253-2266
Main Authors: Lucas, Ricardo, Angulo, Jesús, Nieto, Pedro M, Martín-Lomas, Manuel
Format: Article
Language:English
Subjects:
Carbohydrate Sequence
Heparin - chemistry
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Sequence Data
Molecular Structure
Oligosaccharides - chemical synthesis
Oligosaccharides - chemistry
Protein Conformation
Protein Structure, Secondary
Protein Structure, Tertiary
Sequence Alignment
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Summary:Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.
ISSN:1477-0520
1477-0539
DOI:10.1039/b303115b