4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents

Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive eff...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1977-11, Vol.20 (11), p.1520-1521
Main Authors: Warren, James D, Woodward, David L, Hargreaves, Ronald T
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - chemical synthesis
Antihypertensive Agents - therapeutic use
Benzaldehydes - chemical synthesis
Benzaldehydes - therapeutic use
Dogs
Hypertension - drug therapy
Rats
Semicarbazones - chemical synthesis
Semicarbazones - therapeutic use
Structure-Activity Relationship
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Summary:Twelve 4-substituted semicarbazone derivatives of o- and p-chloro- as well as 2,6-dichlorobenzaldehyde were synthesized and investigated for antihypertensive activity in spontaneously hypertensive rats. Several of the compounds synthesized (viz. 1, 6, 7, and 15) exhibited potent antihypertensive effects when orally administered. The same compounds were not hypotensive in the normotensive dog.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00221a034