Regenerating Axons Reclaim Sensory Targets from Collateral Nerve Sprouts

There is a critical period for the sprouting of intact low-threshold mechanosensory cutaneous nerves in rats; functional invasion of adjacent denervated skin does not occur in animals older than about 20 days of age, and it is largely confined to denervated skin within the ``domain'' of th...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-11, Vol.214 (4523), p.926-928
Main Authors: Jackson, Patrick C., Diamond, Jack
Format: Article
Language:English
Subjects:
Aging
Animals
Axons
Axons - physiology
Behavioral neuroscience
Eyes
Innervation
Mechanoreceptors
Mechanoreceptors - physiology
Nerve Regeneration
Nerves
Neurons
Nociceptors - physiology
Rats
Sense of touch
Skin
Skin - growth & development
Skin - innervation
Space life sciences
Sprouting
Sprouts
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Summary:There is a critical period for the sprouting of intact low-threshold mechanosensory cutaneous nerves in rats; functional invasion of adjacent denervated skin does not occur in animals older than about 20 days of age, and it is largely confined to denervated skin within the ``domain'' of the parent dermatome. These nerves can regenerate readily in the adult, however, and such regenerating nerves do not respect domain borders; moreover, they functionally displace endings of intact nerves that earlier had sprouted into denervated skin.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7302568