Phototherapy-Induced Hypocalcemia in Newborn Rats: Prevention by Melatonin

When young rats are exposed to white fluorescent light the concentration of calcium in their serum decreases. This effect is prevented by shielding the occiput, by inhibiting corticosterone synthesis, and by exogenous melatonin. Furthermore, the expected hypocalcemic response to cortisol injection i...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-11, Vol.214 (4522), p.807-809
Main Authors: Hakanson, David O., Bergstrom, William H.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - radiation effects
Blood
Cadmium
Calcium
Chondrocalcinosis
Diphosphates
Disease Models, Animal
Family members
Female
Fibroblasts
Humans
Hydrocortisone - antagonists & inhibitors
Hyperbilirubinemia
Hypocalcemia
Hypocalcemia - etiology
Hypocalcemia - prevention & control
Infant, Newborn
Jaundice, Neonatal - therapy
Light
Male
Melatonin - pharmacology
Phototherapy
Phototherapy - adverse effects
Rats
Spectrum Analysis
Time Factors
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Summary:When young rats are exposed to white fluorescent light the concentration of calcium in their serum decreases. This effect is prevented by shielding the occiput, by inhibiting corticosterone synthesis, and by exogenous melatonin. Furthermore, the expected hypocalcemic response to cortisol injection is prevented by melatonin. Light-induced hypocalcemia may result from increased calcium uptake by bone when the blocking effect of melatonin decreases after pineal inhibition by transcranial illumination.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6895262