Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

Four human neuroblastoma cell lines were studied by chromosome banding techniques. All of the lines contained a marker chromosome with a long nonbanding homogeneously staining region (HSR). The HSR-containing chromosome differed in each line. One line contained two classes of cells: one with an HSR...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-11, Vol.198 (4318), p.739-741
Main Authors: Balaban-Malenbaum, Gloria, Gilbert, Fred
Format: Article
Language:English
Subjects:
Cell Line
Cell lines
Chromosome Aberrations
Chromosomes
Chromosomes, Human - ultrastructure
DNA
Fructans
Gene amplification
Humans
Karyotyping
Metaphase
Neuroblastoma
Neuroblastoma - ultrastructure
Neurons
Staining and Labeling
Tumor cell line
Tumors
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Summary:Four human neuroblastoma cell lines were studied by chromosome banding techniques. All of the lines contained a marker chromosome with a long nonbanding homogeneously staining region (HSR). The HSR-containing chromosome differed in each line. One line contained two classes of cells: one with an HSR marker chromosome and the other with double minute chromosomes. Each cell had one of these abnormalities; no cell had both. The presence of two additional chromosomal markers in all cells of this line indicates a common origin. These observations suggest that the double minute chromosomes are derived from the HSR.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.71759