A Mechanism for the Biochemical Interaction of Heparin with Cellular Membranes Damaged by X Radiation

The effect of X radiation on the membranes of heparinized and of nonheparinized Ehrlich ascites tumor (E.A.T.) cells was investigated by using the technique of micro-electrophoresis. Exposure to 6000 R significantly decreased the anodic electrophoretic mobility of E.A.T. cells measured 5-6 hr later,...

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Bibliographic Details
Published in:Radiation research 1977-11, Vol.72 (2), p.246-264
Main Authors: McConnell, Val, Kench, James E.
Format: Article
Language:English
Subjects:
Animals
Ascitic Fluid
Carcinoma, Ehrlich Tumor
Cell Line
Cell lines
Cell Membrane - enzymology
Cell Membrane - radiation effects
Cell membranes
Chemical suspensions
Electrophoresis
Enzyme Activation
Fatty Acids, Nonesterified - metabolism
Heparin
Heparin - metabolism
Heparin - pharmacology
In Vitro Techniques
Irradiation
Lipase - metabolism
Lipase - pharmacology
Lipoprotein Lipase - metabolism
Lipoproteins
Neuraminidase - pharmacology
Neurons
Radiation damage
Radiation dosage
Space life sciences
Time Factors
X-Rays
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Summary:The effect of X radiation on the membranes of heparinized and of nonheparinized Ehrlich ascites tumor (E.A.T.) cells was investigated by using the technique of micro-electrophoresis. Exposure to 6000 R significantly decreased the anodic electrophoretic mobility of E.A.T. cells measured 5-6 hr later, while the mobility of heparinized E.A.T. cells was increased under similar conditions. A possible mechanism for the biochemical interaction of heparin with cellular membranes damaged by radiation was tested experimentally. Observations were consistent with the proposed mechanism.
ISSN:0033-7587
1938-5404
DOI:10.2307/3574695