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A Mechanism for the Biochemical Interaction of Heparin with Cellular Membranes Damaged by X Radiation

The effect of X radiation on the membranes of heparinized and of nonheparinized Ehrlich ascites tumor (E.A.T.) cells was investigated by using the technique of micro-electrophoresis. Exposure to 6000 R significantly decreased the anodic electrophoretic mobility of E.A.T. cells measured 5-6 hr later,...

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Published in:	Radiation research 1977-11, Vol.72 (2), p.246-264
Main Authors:	McConnell, Val, Kench, James E.
Format:	Article
Language:	English
Subjects:	Animals Ascitic Fluid Carcinoma, Ehrlich Tumor Cell Line Cell lines Cell Membrane - enzymology Cell Membrane - radiation effects Cell membranes Chemical suspensions Electrophoresis Enzyme Activation Fatty Acids, Nonesterified - metabolism Heparin Heparin - metabolism Heparin - pharmacology In Vitro Techniques Irradiation Lipase - metabolism Lipase - pharmacology Lipoprotein Lipase - metabolism Lipoproteins Neuraminidase - pharmacology Neurons Radiation damage Radiation dosage Space life sciences Time Factors X-Rays
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container_title	Radiation research
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creator	McConnell, Val Kench, James E.
description	The effect of X radiation on the membranes of heparinized and of nonheparinized Ehrlich ascites tumor (E.A.T.) cells was investigated by using the technique of micro-electrophoresis. Exposure to 6000 R significantly decreased the anodic electrophoretic mobility of E.A.T. cells measured 5-6 hr later, while the mobility of heparinized E.A.T. cells was increased under similar conditions. A possible mechanism for the biochemical interaction of heparin with cellular membranes damaged by radiation was tested experimentally. Observations were consistent with the proposed mechanism.
doi_str_mv	10.2307/3574695
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Exposure to 6000 R significantly decreased the anodic electrophoretic mobility of E.A.T. cells measured 5-6 hr later, while the mobility of heparinized E.A.T. cells was increased under similar conditions. A possible mechanism for the biochemical interaction of heparin with cellular membranes damaged by radiation was tested experimentally. 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Observations were consistent with the proposed mechanism.</description><subject>Animals</subject><subject>Ascitic Fluid</subject><subject>Carcinoma, Ehrlich Tumor</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell Membrane - enzymology</subject><subject>Cell Membrane - radiation effects</subject><subject>Cell membranes</subject><subject>Chemical suspensions</subject><subject>Electrophoresis</subject><subject>Enzyme Activation</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Heparin</subject><subject>Heparin - metabolism</subject><subject>Heparin - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Irradiation</subject><subject>Lipase - metabolism</subject><subject>Lipase - pharmacology</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Lipoproteins</subject><subject>Neuraminidase - pharmacology</subject><subject>Neurons</subject><subject>Radiation damage</subject><subject>Radiation dosage</subject><subject>Space life sciences</subject><subject>Time Factors</subject><subject>X-Rays</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoP4ta7iH_CQg-ipmjRJ0xzX9WMXVgRR8FamaWojbbMmLbL_3i5dvHkahveZh-FF6JySm5gRecuE5IkSe2hCFUsjwQnfRxNCGIukSOUxOgnhiww7TdQROlQ0jYWaIDPDz0ZX0NrQ4NJ53FUG31mnK9NYDTVetp3xoDvrWuxKvDBr8LbFP7ar8NzUdV-DHxRN7qE1Ad9DA5-mwPkGf-BXKCxsL0_RQQl1MGe7OUXvjw9v80W0enlazmerSDNGu0hQxmWSAqex5CU3ItckL0kMTKhcc6YkgZgWJIk1BQmSpWWuC8J0oktNiGZTdDV619599yZ0WWODHr4cfnN9yCQbKlKMD-D1CGrvQvCmzNbeNuA3GSXZts9s1-dAXuyUfd6Y4o8bCxziyzH-Cp3z_1p-AWZ7efg</recordid><startdate>197711</startdate><enddate>197711</enddate><creator>McConnell, Val</creator><creator>Kench, James E.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197711</creationdate><title>A Mechanism for the Biochemical Interaction of Heparin with Cellular Membranes Damaged by X Radiation</title><author>McConnell, Val ; Kench, James E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-5134768a41274f4e5bc0bf02a359bc43970a21d062c1a7a738fbcd03c6cfc00c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Ascitic Fluid</topic><topic>Carcinoma, Ehrlich Tumor</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell Membrane - enzymology</topic><topic>Cell Membrane - radiation effects</topic><topic>Cell membranes</topic><topic>Chemical suspensions</topic><topic>Electrophoresis</topic><topic>Enzyme Activation</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Heparin</topic><topic>Heparin - metabolism</topic><topic>Heparin - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Irradiation</topic><topic>Lipase - metabolism</topic><topic>Lipase - pharmacology</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Lipoproteins</topic><topic>Neuraminidase - pharmacology</topic><topic>Neurons</topic><topic>Radiation damage</topic><topic>Radiation dosage</topic><topic>Space life sciences</topic><topic>Time Factors</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McConnell, Val</creatorcontrib><creatorcontrib>Kench, James E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McConnell, Val</au><au>Kench, James E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Mechanism for the Biochemical Interaction of Heparin with Cellular Membranes Damaged by X Radiation</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1977-11</date><risdate>1977</risdate><volume>72</volume><issue>2</issue><spage>246</spage><epage>264</epage><pages>246-264</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The effect of X radiation on the membranes of heparinized and of nonheparinized Ehrlich ascites tumor (E.A.T.) cells was investigated by using the technique of micro-electrophoresis. 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language	eng
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source	JSTOR Archival Journals
subjects	Animals Ascitic Fluid Carcinoma, Ehrlich Tumor Cell Line Cell lines Cell Membrane - enzymology Cell Membrane - radiation effects Cell membranes Chemical suspensions Electrophoresis Enzyme Activation Fatty Acids, Nonesterified - metabolism Heparin Heparin - metabolism Heparin - pharmacology In Vitro Techniques Irradiation Lipase - metabolism Lipase - pharmacology Lipoprotein Lipase - metabolism Lipoproteins Neuraminidase - pharmacology Neurons Radiation damage Radiation dosage Space life sciences Time Factors X-Rays
title	A Mechanism for the Biochemical Interaction of Heparin with Cellular Membranes Damaged by X Radiation
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