Thymosin Stimulates Secretion of Luteinizing Hormone--Releasing Factor

Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin $\beta _{4}$, but not thymosin $\alpha _{1}$, stimulated secretion of luteinizing hormone—releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing h...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-11, Vol.214 (4521), p.669-671
Main Authors: Rebar, Robert W., Miyake, Akira, Teresa L. K. Low, Goldstein, Allan L.
Format: Article
Language:English
Subjects:
Animals
Endocrinology
Fractions
Gonadotropin-Releasing Hormone - metabolism
Hormones
Hormones - pharmacology
Hypothalamo-Hypophyseal System - drug effects
Hypothalamus - drug effects
Intravenous injections
Luteinization
Mice
Peptide Fragments - pharmacology
Pituitary gland
Pituitary hormone releasing factors
Pituitary hormone releasing hormones
Rats
Secretion
Structure-Activity Relationship
Thymic hormones
Thymosin - pharmacology
Thymus gland
Thymus Hormones - pharmacology
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Summary:Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin $\beta _{4}$, but not thymosin $\alpha _{1}$, stimulated secretion of luteinizing hormone—releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing hormone was released from pituitary glands superfused in sequence with hypothalami. No release of luteinizing hormone in response to thymosin was observed from pituitaries superfused alone. These data provide the first evidence of a direct effect of the endocrine thymus on the hypothalamus and suggest a potentially important role for thymic peptides in reproductive function.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7027442