Epileptic seizures and syndromes in twins: the importance of genetic factors

The role of genetic factors in the occurrence of epilepsy syndromes was studied in twins recruited from the population-based Danish Twin Registry. A total of 34,076 twins were screened for epilepsy. Cases were confirmed and classified by two neurologists according to the classification systems of th...

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Bibliographic Details
Published in:Epilepsy research 2003-06, Vol.55 (1), p.137-146
Main Authors: Kjeldsen, Marianne Juel, Corey, Linda A., Christensen, Kaare, Friis, Mogens Laue
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Chi-Square Distribution
Concordance
Databases, Genetic - statistics & numerical data
Diseases in Twins - epidemiology
Diseases in Twins - genetics
Epilepsy
Epilepsy - epidemiology
Epilepsy - genetics
Female
Genetic Markers - genetics
Genetics
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Heritability
Humans
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Seizures
Syndrome
Twins
Twins, Dizygotic - genetics
Twins, Dizygotic - statistics & numerical data
Twins, Monozygotic - genetics
Twins, Monozygotic - statistics & numerical data
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Summary:The role of genetic factors in the occurrence of epilepsy syndromes was studied in twins recruited from the population-based Danish Twin Registry. A total of 34,076 twins were screened for epilepsy. Cases were confirmed and classified by two neurologists according to the classification systems of the International League Against Epilepsy (ILAE). A total of 214 twin pairs with epileptic seizures and 190 pairs with epilepsy were ascertained. Significantly higher concordance rates were found for monozygotic (MZ) compared to dizygotic (DZ) twins for both epileptic seizures (0.56 for MZ and 0.21 for DZ pairs, P
ISSN:0920-1211
1872-6844
DOI:10.1016/S0920-1211(03)00117-7