Participation of Free Oxygen Radicals in Damage of Porcine Erythrocytes

Gamma radiation causes disturbances in energy metabolism, decreases in (${\rm Na}^{+}-{\rm K}^{+}$)-ATPase, Mg2+-APTase activity, and increase in the degree of hemolysis in porcine erythrocytes. Our results indicated a contribution of exogenous free radicals in radiation damage to porcine erythrocyt...

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Bibliographic Details
Published in:Radiation research 1981-10, Vol.88 (1), p.11-19
Main Authors: Jóźwiak, Z., Helszer, Z.
Format: Article
Language:English
Subjects:
Adenosine triphosphatases
Adenosine Triphosphatases - metabolism
Animals
Ca(2+) Mg(2+)-ATPase
Cell membranes
Energy metabolism
Energy Metabolism - radiation effects
Erythrocyte membrane
Erythrocyte Membrane - enzymology
Erythrocytes
Erythrocytes - drug effects
Erythrocytes - radiation effects
Free Radicals
Gamma Rays
Hemolysis
In Vitro Techniques
Oxygen
Radiation damage
Radiation dosage
Radiation-Protective Agents - pharmacology
Sodium-Potassium-Exchanging ATPase - metabolism
Space life sciences
Superoxide Dismutase
Superoxides
Swine
Water - radiation effects
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Summary:Gamma radiation causes disturbances in energy metabolism, decreases in (${\rm Na}^{+}-{\rm K}^{+}$)-ATPase, Mg2+-APTase activity, and increase in the degree of hemolysis in porcine erythrocytes. Our results indicated a contribution of exogenous free radicals in radiation damage to porcine erythrocytes. In the presence of biological and chemical radioprotectors a protective effect with respect to ATPase activity and energy metabolism was observed in the presence of superoxide dismutase, cysteine, and glutathione, with respect to hemolysis in the presence of catalase, histidine, glucose, and sulfhydryl compounds. It appears that radiation damage to porcine erythrocytes is due to the action of various radicals formed upon irradiation which react at different rates with various cell constituents.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575746