Glycogen‐rich clear cell carcinoma of the breast: A light and electron microscopic study

A glycogen‐rich clear cell carcinoma arose in the breast of a 49‐year‐old woman. Light microscopic examination of the neoplasm revealed both intraductal papillary growth and stromal invasion. Electron microscopic examination demonstrated neoplastic cells that contained massive quantities of nonmembr...

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Bibliographic Details
Published in:Cancer 1981-11, Vol.48 (9), p.2003-2009
Main Authors: Hull, Meredith T., Priest, John B., Broadie, Thomas A., Ransburg, Robert C., McCarthy, Leo J.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Papillary - metabolism
Adenocarcinoma, Papillary - ultrastructure
Breast Neoplasms - metabolism
Breast Neoplasms - ultrastructure
Female
Glycogen - analysis
Humans
Inclusion Bodies - ultrastructure
Intercellular Junctions - ultrastructure
Middle Aged
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Summary:A glycogen‐rich clear cell carcinoma arose in the breast of a 49‐year‐old woman. Light microscopic examination of the neoplasm revealed both intraductal papillary growth and stromal invasion. Electron microscopic examination demonstrated neoplastic cells that contained massive quantities of nonmembrane‐bound particulate glycogen and that formed numerous acini. Apically, these cells formed microvilli; laterally they formed tight junctions and desmosomes. Morphologic features of this neoplasm are similar to those of the fetal breast and to some other clear cell carcinomas arising elsewhere in the body.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19811101)48:9<2003::AID-CNCR2820480916>3.0.CO;2-Q