Effect of vasoactive intestinal polypeptide on cerebral blood flow in the goat

The effect of vasoactive intestinal polypeptide (VIP) on the cerebral blood flow was investigated in the goat. An electromagnetic flow probe was placed around the internal maxillary artery for continuous measurement of ipsilateral blood flow. Intraarterial injection of VIP resulted in a dose‐depende...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1981-04, Vol.111 (4), p.471-474
Main Authors: LARSEN, JENS-JØRGEN, BOECK, VITA, OTTESEN, BENT
Format: Article
Language:English
Subjects:
Animals
Atropine - pharmacology
cerebral blood flow
Cerebrovascular Circulation - drug effects
Dose-Response Relationship, Drug
Gastrointestinal Hormones - physiology
Goat
Goats - physiology
Naloxone - pharmacology
Phentolamine - pharmacology
Propranolol - pharmacology
Vasoactive Intestinal Peptide - physiology
VIP
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Summary:The effect of vasoactive intestinal polypeptide (VIP) on the cerebral blood flow was investigated in the goat. An electromagnetic flow probe was placed around the internal maxillary artery for continuous measurement of ipsilateral blood flow. Intraarterial injection of VIP resulted in a dose‐dependent increase in the cerebral blood flow. The effect was not antagonized by any of the antagonists atropine, propranolol, phentolamine and naloxone administered intraarterially 1 min before VIP. It is discussed that VIP may play a physiological role in the local blood flow regulation in the CNS.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1981.tb06765.x