Granulopoiesis Associated With the C3HBA Tumor in Mice

Female C3H/HeJ mice were inoculated with syngeneic breast adenocarcinoma cells (C3HBA). A progressive neutrophilia developed as the tumors grew. A linear relationship was demonstrated between the tumor diameter and the extent of the neutrophilia. Local tumor excision caused a rapid fall (3 days) in...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1981-11, Vol.67 (5), p.1135-1138
Main Authors: Lan, Sam, Rettura, Giuseppe, Levenson, Stanley M., Seifter, Eli
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - metabolism
Animals
Bone Marrow - physiology
Female
Hematopoiesis
Leukocytosis - etiology
Mammary Neoplasms, Experimental - blood
Mammary Neoplasms, Experimental - metabolism
Mice
Mice, Inbred C3H
Neutrophils
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Summary:Female C3H/HeJ mice were inoculated with syngeneic breast adenocarcinoma cells (C3HBA). A progressive neutrophilia developed as the tumors grew. A linear relationship was demonstrated between the tumor diameter and the extent of the neutrophilia. Local tumor excision caused a rapid fall (3 days) in the neutrophil count. Media conditioned with tumor cells, normal mouse kidney, and bone marrow of normal or tumor-bearing mice were prepared. Tumor cell-conditioned medium was found to have marked stimulating activity for granulocytic colony formation of mouse bone marrow cells. Sera from tumor-bearing mice also had colony-stimulating activity. This finding strongly suggested that the neutrophilia was caused by the release of a neutrophil-stimulating factor from the tumor.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/67.5.1135