Pulmonary function and bronchial hyperreactivity in long-term survivors of bronchopulmonary dysplasia

Nine children with bronchopulmonary dysplasia were studied at a mean age of 8.4 years. Persistent respiratory symptoms were common. Pulmonary function tests demonstrated airway obstruction and abnormal blood gas levels in most. In six of eight children results of methacholine challenge tests were po...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1981-09, Vol.68 (3), p.336-340
Main Authors: Smyth, J A, Tabachnik, E, Duncan, W J, Reilly, B J, Levison, H
Format: Article
Language:English
Subjects:
Bronchial Provocation Tests
Bronchopulmonary Dysplasia - physiopathology
Carbon Dioxide - blood
Child
Female
Forced Expiratory Volume
Humans
Infant, Newborn
Lung - physiopathology
Male
Maximal Midexpiratory Flow Rate
Oxygen - blood
Residual Volume
Respiratory Function Tests
Total Lung Capacity
Vital Capacity
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Summary:Nine children with bronchopulmonary dysplasia were studied at a mean age of 8.4 years. Persistent respiratory symptoms were common. Pulmonary function tests demonstrated airway obstruction and abnormal blood gas levels in most. In six of eight children results of methacholine challenge tests were positive, indicating bronchial hyperreactivity. Abnormal chest radiographs persisted in eight children. The bronchial hyperreactivity is a likely consequence of airway damage in infancy and is the probable reason for episodic wheezing in the early years of life. Improvement in expiratory flow rates following bronchodilator inhalation suggests that such therapy may improve function in these children.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.68.3.336