Effects of pulse and continuous intravenous infusion of cis-diamminedichloroplatinum on L1210 leukemia in vivo

The in vivo effects of cis-diamminedichloroplatinum on L1210 leukemia were determined using DNA content distribution analysis by flow microfluorometry and pulse [3H]thymidine labeling indices. Pulse and continuous infusion schedules were investigated. Pulse cis-diamminedichloroplatinum (2 and 6 mg/k...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1981-12, Vol.41 (12 Pt 1), p.4993-4996
Main Authors: Moran, R E, Straus, M J
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - drug effects
Cell Division - drug effects
Cell Survival - drug effects
Cisplatin - administration & dosage
Drug Administration Schedule
Injections, Intraperitoneal
Injections, Intravenous
Leukemia L1210 - drug therapy
Male
Mice
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Summary:The in vivo effects of cis-diamminedichloroplatinum on L1210 leukemia were determined using DNA content distribution analysis by flow microfluorometry and pulse [3H]thymidine labeling indices. Pulse and continuous infusion schedules were investigated. Pulse cis-diamminedichloroplatinum (2 and 6 mg/kg) resulted in progression delay of cells in S and G2 phases and at higher doses (greater than or equal to 12 mg/kg) in G1 as well. Equivalent total doses administered by continuous infusion over 24 to 72 hr delayed cells in G2 with little apparent affect on G1 or S progression. A maximum survival of 70% increased life span over controls was achieved with a 12-mg/kg pulse. Infusion doses at least 2-fold higher were required to achieve similar increases in survival. Cell cycle changes did not predict for therapeutic benefit, suggesting that, at suboptimal doses, cells were capable of repair. The therapeutic index for both modes of administration was narrow.
ISSN:0008-5472